APIGEN 0.3% price in UAE

Overview

Welcome to Dwaey, specifically on APIGEN 0.3% Eye / Ear Drops (Solution) page.
This medicine contains an important and useful components, as it consists of Gentamicin (as sulphate).
APIGEN 0.3% is available in the market in concentration 3mg/ml and in the form of Eye / Ear Drops (Solution).

AMMAN PHARMACEUTICAL INDUSTRIES CO. LTD. is the producer of APIGEN 0.3% and it is imported from JORDAN, The most popular alternatives of APIGEN 0.3% are listed downward .

Mode Of Action

Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Indication

Pneumonia
Cystic fibrosis
Meningitis
Peritonitis
Endocarditis
Susceptible infections
Septicaemia
Pelvic inflammatory disease
Endometritis
Biliary tract infections
Granuloma inguinale
Listeriosis
Gastroenteritis
Plague
Cat scratch disease
Brucellosis
Otitis externa
Surgical infections
Skin infections.

Precaution

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum. Lactation: Enters breast milk; use with caution (AAP Committee states "compatible with nursing")

Side Effects

>10% Neurotoxicity (vertigo
ataxia)
Gait instability
Ototoxicity (auditory
vestibular)
Nephrotoxicity (decreased CrCl)
Nephrotoxicity if trough >2 mg/L 1-10% Edema
Rash
Reddening of skin
Itching <1% Drowsiness
Headache
Pseudomotor cerebri
Photosensitivity
Allergic reaction
Erythema
Anorexia
Nausea/vomiting
Weight loss
Increased salivation
Enterocolitis
Granulocytopenia
Agranulocytosis
Thrombocytopenia
Elevated LFT Burning
Stinging
Tremors
Muscle cramps
Weakness
Dyspnea Potentially Fatal: Nephrotoxicity
ototoxicity and neuromuscular blockade (may unmask or aggravate myasthaenia gravis).

Contra indication

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.

Pregnancy and lactation

Pregnancy category: D

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Interaction

Synergistic with ampicillin, benzylpenicillin and other beta-lactam antibiotics. Increased risk of severe respiratory depression when used concurrently with anaesthetics or opioids. May reduce renal clearance of zalcitabine and induce hypocalcaemia when used with biphosphonates. Not to be used with agalsidase alfa or beta as it may inhibit alpha-galactosidase activity. Potentially Fatal: Increased incidence of ototoxicity when combined with ethacrynic acid and furosemide. Cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone and indometacin potentiate nephrotoxicity. Potentiates neuromuscular blocking agents.