ANUSOL H.C Price

Overview

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This medicine contains an important and useful components, as it consists of
Benzyl benzoate, Bismuth oxide, Bismuth subgallate, Peru balsm, Zinc oxideis available in the market in concentration

Name

Ticlopidine Hydrochloride

Precaution

Before starting **Ticlopidine Hydrochloride**, it is critical for patients to consult their healthcare provider to ensure that the drug is appropriate for their specific condition. Several precautions need to be observed: - **Bleeding Disorders**: **Ticlopidine** is an antiplatelet drug, which can increase the risk of bleeding. Patients with a history of **bleeding disorders**, such as **hemophilia**, **gastrointestinal bleeding**, or **intracranial hemorrhage**, should use this drug with caution. The risk of bleeding complications may be more pronounced in patients who have recently undergone surgery or trauma. - **Liver Disease**: **Ticlopidine** can affect liver function. Patients with **liver diseases** like **cirrhosis** or **hepatitis** should be monitored carefully, as they may be at greater risk for side effects due to impaired drug metabolism. - **Bone Marrow Suppression**: Long-term use of **Ticlopidine** has been associated with **bone marrow suppression**, which can lead to **leukopenia**, **neutropenia**, or **thrombocytopenia**. Blood counts should be regularly monitored, especially during the first few months of treatment. - **Pregnancy and Breastfeeding**: **Ticlopidine** is classified as a **Category B** drug during pregnancy, which means that animal studies have not shown risk to the fetus, but adequate human studies are lacking. Therefore, it should only be used during pregnancy if absolutely necessary. It is not known if **Ticlopidine** is excreted in breast milk, so nursing mothers should consult a doctor before using this medication. - **Renal Impairment**: **Ticlopidine** should be used with caution in patients with **renal insufficiency**, as the drug's excretion may be affected, and renal impairment may exacerbate potential side effects.

Indication

**Ticlopidine Hydrochloride** is primarily used for its **antiplatelet** properties, preventing blood clots in various conditions: - **Prevention of Stroke**: **Ticlopidine** is used to prevent recurrent strokes in patients who have had a **transient ischemic attack (TIA)** or **ischemic stroke**. It reduces the risk of thrombus formation that could lead to another stroke. - **Acute Coronary Syndrome**: It is also prescribed for individuals suffering from **acute coronary syndrome (ACS)**, including patients who are at high risk for **heart attack** or **cardiovascular events**. - **Peripheral Artery Disease**: **Ticlopidine** is used in patients with **peripheral artery disease (PAD)** to prevent thrombus formation and reduce the risk of complications like gangrene and limb amputation. - **Post-Stent Placement**: In patients who have undergone **percutaneous coronary intervention (PCI)** with stent placement, **Ticlopidine** may be used to prevent blood clots and restenosis (narrowing of the artery due to clot formation).

Contra indication

Certain conditions make the use of **Ticlopidine Hydrochloride** unsafe: - **Active Bleeding**: **Ticlopidine** is contraindicated in patients who are actively bleeding or have a known **bleeding disorder** like **hemophilia**, **peptic ulcer disease**, or **intracranial bleeding**. - **Severe Liver Disease**: Patients with **severe liver disease** or **hepatitis** should not use **Ticlopidine**, as the drug can worsen liver function or increase the risk of severe side effects. - **Hypersensitivity**: Patients with a known allergy or hypersensitivity to **Ticlopidine** or other **thienopyridines** (such as **clopidogrel**) should avoid using the drug to prevent an allergic reaction. - **Thrombocytopenia or Leukopenia**: Individuals with pre-existing **thrombocytopenia** (low platelets) or **leukopenia** (low white blood cell count) should not use **Ticlopidine**, as it can further suppress bone marrow activity. - **Pregnancy**: As **Ticlopidine** is a Category B drug, it should only be used in pregnancy if the benefits outweigh the risks. It should be avoided during breastfeeding due to a lack of data on its safety during lactation.

Side Effect

Common and severe side effects associated with **Ticlopidine** include: - **Common Side Effects**: - **Gastrointestinal Issues**: These include **nausea**, **vomiting**, **diarrhea**, and **indigestion**. Gastrointestinal discomfort is relatively common and often transient. - **Rash**: Skin rashes or **urticaria** may occur in some patients, particularly in the early stages of treatment. - **Fatigue**: Patients may experience tiredness or weakness, which is generally mild but can impact daily functioning. - **Serious Side Effects**: - **Neutropenia**: **Ticlopidine** has been associated with a **decrease in white blood cells** (neutropenia), which can increase the risk of infections. Blood counts should be monitored, especially in the first three months of therapy. - **Thrombocytopenia**: **Low platelet counts** can lead to bleeding tendencies, such as easy bruising or prolonged bleeding from cuts. - **Bone Marrow Suppression**: Long-term use may cause **bone marrow suppression**, leading to **leukopenia** (reduced white blood cells) or **thrombocytopenia**. - **Severe Allergic Reactions**: Rarely, patients may experience severe allergic reactions, such as **angioedema** (swelling of deeper layers of the skin), difficulty breathing, or **anaphylaxis**. Patients should seek immediate medical help if they experience symptoms like excessive bruising, persistent fever, mouth sores, or unusual tiredness, as these may indicate serious side effects.

Pregnancy Category ID

2

Mode of Action

**Ticlopidine** is an **antiplatelet** medication that works by inhibiting the activation of **platelets**. Its mechanism of action involves the inhibition of **P2Y12** receptors on platelets, which are crucial for platelet aggregation. By blocking these receptors, **Ticlopidine** reduces the ability of platelets to stick together and form clots. This makes it an effective agent in preventing thrombus formation, particularly in patients at risk for conditions like stroke, heart attack, and peripheral artery disease. The drug helps to keep blood flowing smoothly and reduces the chances of dangerous clot formation, particularly in arteries that supply blood to the brain or heart.

Interaction

**Ticlopidine Hydrochloride** has several interactions with other medications, which may increase or decrease its effectiveness, or exacerbate side effects: - **Anticoagulants**: When combined with anticoagulants such as **warfarin**, **heparin**, or **dabigatran**, the risk of **bleeding** is significantly increased. Close monitoring of coagulation parameters (e.g., INR) is essential when used together. - **Other Antiplatelet Drugs**: Combining **Ticlopidine** with other antiplatelet drugs like **aspirin**, **clopidogrel**, or **prasugrel** increases the risk of bleeding. It is important that healthcare providers carefully consider the patient's bleeding risk before prescribing multiple antiplatelet medications. - **CYP450 Inhibitors**: Drugs that inhibit the **CYP450 enzyme system**, such as **fluoxetine**, **fluconazole**, and **erythromycin**, may increase the blood levels of **Ticlopidine**, leading to an increased risk of bleeding. These interactions should be avoided or carefully managed. - **NSAIDs**: Nonsteroidal anti-inflammatory drugs (e.g., **ibuprofen**, **naproxen**) can also increase the bleeding risk when taken with **Ticlopidine**. - **Proton Pump Inhibitors (PPIs)**: Some evidence suggests that the use of **PPIs** like **omeprazole** may reduce the efficacy of **Ticlopidine**. These should be used cautiously in patients on **Ticlopidine**.

Pregnancy Category Note

Information not available

Adult Dose

The recommended dose of **Ticlopidine** for adults is: - **Initial Dose**: **250 mg** twice daily for the first 2 weeks. - **Maintenance Dose**: After 2 weeks, the typical maintenance dose is **250 mg** once or twice daily, depending on the patient's condition. The dosage may vary depending on the severity of the condition being treated, so it is essential to follow the prescribing healthcare provider’s recommendations.

Child Dose

**Ticlopidine** is not generally recommended for use in pediatric patients. The safety and efficacy of the drug in children have not been established. In pediatric patients, alternative therapies for the management of thrombotic conditions should be considered under the guidance of a healthcare provider. Always consult a pediatrician or healthcare provider for appropriate treatment options.

Renal Dose

**Ticlopidine** should be used with caution in patients with **renal impairment**. Since **Ticlopidine** is primarily eliminated through the liver, renal function does not typically require adjustment. However, in patients with **severe renal insufficiency**, the use of **Ticlopidine** should be carefully considered, and the drug should be monitored closely for side effects, especially bleeding risks.

Administration

Information not available