TASIGNA 150mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Nilotinib (as HCl H2O)is available in the market in concentration

Name

Nilotinib

Precaution

Patient w/ history of pancreatitis, w/ total gastrectomy. Hepatic impairment. Maintain adequate hydration and correct uric acid levels, hypomagnesaemia, hypokalaemia and other electrolyte imbalances prior to therapy. Pregnancy and lactation. Monitoring Parameters Monitor ECG, CBC, hepatic function, serum lipase regularly. Monitor electrolyte periodically during therapy. Lactation: not known if excreted in breast milk; do not nurse

Indication

Chronic myelogenous leukaemia

Contra indication

Patients with hypokalaemia, hypomagnaesemia or long QT syndrome. Pregnancy.

Side Effect

>10% Rash (33%),Headache (31%),Nausea (31%),Pruritus (29%),Fatigue (28%),Pyrexia (24%),Diarrhea (22%),Constipation (21%),Vomiting (21%),Arthralgia (18%),Cough (17%),Extremity pain (16%),Asthenia (14%),Muscle spasms (14%),Myalgia (14%),Abdominal pain (13%),Bone pain (13%),Back pain (12%),Dyspnea (11%),Nasopharyngitis (11%),Peripheral edema (11%) 1-10% (selected) Dizziness,Insomnia,Paresthesia,QT interval prolongation,HTN,Palpitations,QT interval prolongation,Hyperglycemia,Hyperkalemia,Hypomagnesemia,Neutropenia,Pancytopenia <1% Peripheral arterial occlusive disease,Tumor lysis syndrome,Aortic valve sclerosis,Abscess,Amnesia,Dehydration Potentially Fatal: QT prolongation and sudden deaths.

Pregnancy Category ID

4

Mode of Action

Nilotinib is a potent inhibitor of BCR-ABL tyrosine kinase. It binds to and stabilises the inactive conformation of the kinase domain of Abl protein.

Interaction

Drugs that inhibit gastric acid secretion (e.g. PPIs) may reduce solubility and bioavailability of nilotinib. Potentially Fatal: Concomitant use w/ potent CYP3A4 inhibitors or antiarrhythmics (e.g. amiodarone, disopyramide, quinidine, sotalol, ketoconazole, clarithromycin, atazanavir) and other QT prolonging drugs (e.g. chloroquine, haloperidol, methadone, moxifloxacin, pimozide) may increase nilotinib serum levels and/or increase the risk of QT prolongation. Concomitant use w/ potent CYP3A4 inducers (e.g. rifampcin, phenobarbital, carbamazepine, phenytoin) may decrease nilotinib serum levels.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration