Active Substance: Pneumococcal polysaccharide from each of 10 capsular types of Streptococcus pneumoniae (conjugated to carrier proteins of Diphtheria toxoid, H. influenzae & Tetanus toxoid), adsorbed.
Overview
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This medicine contains an important and useful components, as it consists of
Pneumococcal polysaccharide from each of 10 capsular types of Streptococcus pneumoniae (conjugated to carrier proteins of Diphtheria toxoid, H. influenzae & Tetanus toxoid), adsorbedis available in the market in concentration
Pneumococcal polysaccharide unconjugated Vaccine
Severe renal, hepatic, cardiac, vascular &/or pulmonary dysfunction. Patients on immunosuppressants may be unable to attain required antibody titres. Pregnancy & lactation. Efficacy may be reduced in multiple myeloma, Hodgkin's and non-Hogkin's lymphoma, especially during treatment and in chronic alcoholism. Vaccine should be given 2 wk before starting immunosuppressive treatment or at least 3 mth after treatment completion.
Prevention of pneumococcal disease
A known allergy to one of the components of the vaccine. Fever or acute disease or a relapse of a chronic disease: It is preferable to postpone vaccination. Vaccination is not recommended for subjects who have been vaccinated within the previous 3 years, unless indicated otherwise. A confirmed or suspected episode of pneumococcal infection is not a contraindication and vaccination should be considered according to the underlying risk status.
Local Reactions at the Injection Site: Pain, erythema (redness), induration and oedema (swelling). These reactions are mild and transient. Rare reactions eg, Arthus phenomenon (severe local reactions) are reversible without after-effects; they mainly occur in subjects with high initial levels of pneumococcal antibody. Moderate and transient hyperthermia (fever) sometimes >39°C which generally occurs very shortly after vaccination and resolves within 24 hrs. Other General Reactions: Adenopathy (inflammation of the lymph nodes), rashes, arthralgia (pain in the joints) and allergic reactions [urticaria, Quincke'soedema (type of urticaria with sudden swelling of the face and neck), anaphylactoid reactions (severe allergic reaction)], headache, muscle pain, malaise, and fatigue have exceptionally been reported.
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S. pneumoniae capsular antigens stimulate active immune response resulting in production of endogenously produced antibodies
Reduce immune response to Zostavax. Immunosuppressives.
Information not available