ANGIOTEC 5 Price

Overview

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This medicine contains an important and useful components, as it consists of
Enalapril maleateis available in the market in concentration

Name

Enalapril Maleate

Precaution

Impaired renal function. Hyperkalaemia, hypovolaemia, collagen vascular disease, valvular stenosis, during or immediately before or after anaesthesia, unilateral renal artery stenosis. Hypotension due to volume depletion, diuretic therapy. Monitor WBC count. Lactation, children.

Indication

Hypertension, Heart failure

Contra indication

Hypersensitivity. History of angioedema due to previous treatment with ACE inhibitors; bilateral renal artery stenosis. Pregnancy.

Side Effect

1-10% Dizziness (4-8%),Hypotension (0.9-6.7%),Headache (2-5%),Chest pain (2%),Cough (1-2%),Rash (1.5%) Frequency Not Defined Asthenia,Nausea,Vomiting,Hyperkalemia Potentially Fatal: Angioedema.

Pregnancy Category ID

3

Mode of Action

Enalapril, a prodrug of enalaprilat, competitively inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention) secretion. This promotes vasodilation and BP reduction.

Interaction

May potentiate hypotensive action w/ diuretics, other antihypertensives, TCAs, nitrates or anaesth. Concomitant admin w/ lithium carbonate may cause lithium toxicity. Increased risk of renal impairment w/ NSAIDs. May increase hyperkalaemic effect w/ K-sparing diuretics and supplements.

Pregnancy Category Note

Pregnancy category: C (1st trimester); D (2nd and 3rd trimesters). During the second and third trimesters of pregnancy, these drugs have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible and irreversible renal failure, and death

Adult Dose

Child Dose

Renal Dose

Administration