SUBOXONE 8mg/2 mg Price

Overview

Welcome to Dwaey, specifically on SUBOXONE 8mg/2 mg page.
This medicine contains an important and useful components, as it consists of
Buprenorphine/Naloxoneis available in the market in concentration

Name

Albumin Human 20%

Precaution

Before initiating treatment with **Albumin Human 20%**, it is essential to consult a healthcare provider to assess the individual’s medical history and any pre-existing conditions. Key precautions include: - **Allergic Reactions**: Although rare, some patients may experience hypersensitivity reactions to human albumin. Symptoms such as **rash**, **fever**, **chills**, **difficulty breathing**, or **swelling** should be promptly addressed, and the infusion should be stopped immediately if such reactions occur. - **Cardiac and Renal Impairment**: Caution is required in patients with **heart failure**, **pulmonary edema**, or **severe kidney disease**, as the infusion of high-concentration albumin may exacerbate these conditions by increasing fluid retention. Close monitoring of fluid balance is essential in these patients. - **Hypervolemia**: Since **Albumin Human 20%** is a higher concentration than standard albumin solutions, it may increase the risk of **fluid overload** if administered too quickly or in excessive amounts. Patients must be carefully monitored for signs of **edema** and **overhydration**. - **Coagulation and Hemorrhage**: Although albumin does not directly affect coagulation, its use in conjunction with anticoagulants or other treatments that affect blood clotting should be carefully managed. There is an increased risk of **bleeding** in patients with **coagulation abnormalities** or who are undergoing anticoagulation therapy.

Indication

**Albumin Human 20%** is primarily indicated for patients who require **plasma volume expansion** and **protein replacement**. Some of the common therapeutic uses include: - **Hypovolemia**: In conditions that cause significant fluid loss, such as trauma, surgery, or severe burns, **Albumin Human 20%** helps restore blood volume and maintain circulatory function by increasing plasma volume. - **Severe Hypoalbuminemia**: It is used to treat **low blood albumin levels** (hypoalbuminemia), which may result from conditions such as **cirrhosis**, **nephrotic syndrome**, **severe burns**, or **protein-losing enteropathy**. - **Shock**: In cases of **hypovolemic shock**, such as post-surgery or trauma, **albumin** can be used as part of the fluid resuscitation protocol to increase blood volume and improve perfusion. - **Liver Disease**: Patients with **liver cirrhosis** or **acute liver failure**, where albumin levels are critically low, may benefit from albumin therapy to help correct **plasma protein deficiency**. - **Post-operative Care**: Following major surgery, **Albumin Human 20%** can aid in maintaining plasma volume and **cardiovascular stability**, particularly after significant blood loss.

Contra indication

**Albumin Human 20%** should not be used in the following circumstances: - **Hypersensitivity to Albumin**: Patients with a known allergy to human albumin or any component of the formulation should avoid this product. - **Severe Hypervolemia**: It should not be used in patients who have **fluid overload**, including those with **pulmonary edema**, **decompensated heart failure**, or **kidney failure**. - **Anemia**: **Albumin** should be avoided in patients with **severe anemia** since it does not contain red blood cells and will not help with oxygen transport. - **Coagulation Disorders**: In patients with **active bleeding** or **severe clotting abnormalities**, albumin should be used with caution, as it does not correct these issues and may worsen the bleeding tendency.

Side Effect

While **Albumin Human 20%** is generally well tolerated, potential side effects include: - **Allergic Reactions**: Symptoms of **allergic reactions** (e.g., rash, hives, shortness of breath, or swelling of the face, lips, or throat) should be promptly managed. **Anaphylactic reactions**, though rare, are possible. - **Fluid Overload**: Patients may experience **fluid overload** resulting in symptoms such as **edema**, **dyspnea** (difficulty breathing), and **pulmonary edema** (fluid accumulation in the lungs). This is especially a risk in patients with heart or kidney disease. - **Hypotension**: A drop in blood pressure may occur after administration of albumin, particularly when used to rapidly restore blood volume. - **Headache or Dizziness**: Some patients may experience **headaches**, **dizziness**, or **nausea** as their fluid balance shifts during the treatment. - **Nausea and Vomiting**: Gastrointestinal symptoms, including nausea and vomiting, may arise, particularly if the infusion rate is too rapid. - **Back Pain or Muscle Pain**: Muscle discomfort or back pain may occur in some patients following albumin infusion. - **Fever and Chills**: Some individuals may experience mild flu-like symptoms, such as **fever** or **chills**, during or after the administration of albumin.

Pregnancy Category ID

3

Mode of Action

**Albumin Human 20%** acts as a **plasma volume expander** by increasing the **oncotic pressure** of blood plasma. Oncotic pressure refers to the pressure exerted by plasma proteins that pulls water into the bloodstream. By infusing albumin, this process helps **restore blood volume**, **maintain circulatory function**, and **improve tissue perfusion**. The high concentration of albumin (20%) in this formulation provides a more concentrated solution, allowing for smaller volumes to be administered compared to lower concentrations of albumin solutions, which is beneficial when dealing with patients requiring rapid volume expansion. Additionally, albumin helps to replace **lost proteins** and support the **osmotic balance** of fluids in conditions like **hypoalbuminemia**, **shock**, or **severe burns**.

Interaction

Interactions with **Albumin Human 20%** may involve both medications and other fluids: - **Diuretics**: When administered together with **diuretics**, albumin can exacerbate fluid imbalances, potentially leading to dehydration or **hypotension**. The combination of these treatments should be monitored closely, especially in patients with heart or kidney problems. - **Anticoagulants**: Albumin does not directly affect coagulation, but in patients receiving anticoagulant therapy, it may alter the plasma volume and distribution of other medications, potentially affecting the anticoagulant’s effectiveness. - **Blood Products**: When **albumin** is used in conjunction with **blood transfusions**, especially in patients with extensive blood loss, careful monitoring of fluid volume and the risk of **overload** is necessary to prevent adverse effects like **pulmonary edema**. - **Corticosteroids**: Corticosteroids can alter fluid balance, and when combined with albumin, the risk of fluid retention and **hypertension** may be increased. Regular monitoring is recommended. - **Vasopressors**: In critically ill patients receiving vasopressor medications to support blood pressure, **albumin** may interact with these drugs to affect **circulatory volume** and **blood pressure**. The patient’s blood pressure should be monitored closely during treatment.

Pregnancy Category Note

Information not available

Adult Dose

The dose of **Albumin Human 20%** varies based on the clinical condition being treated: - For **hypovolemia**, the typical dose is **200-500 mL** per day. In cases of **severe blood loss**, higher volumes may be required. - In patients with **liver cirrhosis** or **nephrotic syndrome**, the dosage generally ranges from **100-300 mL/day** based on the severity of hypoalbuminemia and fluid retention. - For **shock**, initial doses of **200-500 mL** may be used, depending on the patient’s volume status and clinical response. - It should be administered slowly at a rate of **2-4 mL/min**, adjusting based on the patient's tolerance and medical condition.

Child Dose

The dosing for **children** will depend on the child’s weight and clinical condition. For **neonates** or **pediatric patients** with severe hypoalbuminemia or **shock**, the typical dose is **1-2 g/kg body weight**, which can be administered intravenously. For conditions like **severe burns** or **hypovolemia**, dosing may vary, and the treatment should be carefully monitored by a healthcare professional. Infusions should be performed slowly, and any signs of fluid overload or adverse reactions should be monitored and managed promptly. --- **Important Note**: Before initiating **Albumin Human 20%**, it is critical to consult a healthcare provider to assess risks, potential interactions, and ensure the appropriate use of the medication. Regular monitoring of fluid balance, renal and cardiac function, and overall clinical response is necessary to avoid complications.

Renal Dose

No specific dose adjustments are required for **Albumin Human 20%** in patients with **renal impairment**, but these patients should be carefully monitored for **fluid overload**. Albumin administration should be cautious, as it can exacerbate **fluid retention** in patients with kidney failure. If used in patients with **end-stage renal disease**, close monitoring of **electrolytes**, **fluid balance**, and **renal function** is recommended to avoid complications.

Administration

Information not available