STRAUMANN EMDOGAIN Price

Overview

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This medicine contains an important and useful components, as it consists of
Protein (Enamel matrix proteins)is available in the market in concentration

Name

Pilocarpine Hydrochloride

Precaution

Before using Pilocarpine Hydrochloride, it is crucial for patients to consult their healthcare provider, especially if they have any of the following conditions: - **Respiratory conditions**: Pilocarpine may cause bronchoconstriction, so it should be used cautiously in individuals with asthma, chronic obstructive pulmonary disease (COPD), or other respiratory conditions. - **Cardiovascular disorders**: Patients with a history of heart problems, including bradycardia (slow heart rate) or arrhythmias, should be monitored closely, as Pilocarpine may exacerbate these conditions. - **Gastrointestinal issues**: The drug can increase gastrointestinal motility, so it should be used with caution in patients with peptic ulcers, irritable bowel syndrome (IBS), or other gastrointestinal issues. - **Pregnancy and Lactation**: Pilocarpine should be used during pregnancy only if clearly needed, as its safety in pregnant women has not been well-established. It is also excreted in breast milk, so nursing mothers should consult their healthcare provider before use. - **Dehydration or hyperhidrosis**: Because Pilocarpine stimulates sweat production, it should be used cautiously in patients with dehydration or hyperhidrosis (excessive sweating).

Indication

Pilocarpine Hydrochloride is a parasympathomimetic drug commonly prescribed for the following indications: - **Glaucoma**: Pilocarpine is used to treat open-angle glaucoma and acute angle-closure glaucoma. It works by increasing the outflow of aqueous humor, thereby reducing intraocular pressure. - **Dry Mouth (Xerostomia)**: Pilocarpine is used to treat dry mouth resulting from conditions like **Sjögren's syndrome**, radiation therapy for head and neck cancers, and certain medications that reduce saliva production. - **Post-surgical effects**: In some cases, Pilocarpine is used to treat dry mouth or difficulty swallowing that can occur after certain surgeries, such as those involving the salivary glands. - **Cystic fibrosis**: It may be used in sweat tests to help measure chloride secretion in patients with cystic fibrosis.

Contra indication

Pilocarpine Hydrochloride should not be used in the following conditions: - **Hypersensitivity**: Patients who have a known allergy or hypersensitivity to Pilocarpine or any of its components should not use this medication. - **Severe asthma or COPD**: Pilocarpine can worsen respiratory conditions due to its cholinergic effects, and therefore it is contraindicated in patients with severe obstructive lung disease. - **Acute iritis or uveitis**: Since Pilocarpine causes miosis (pupil constriction), it may increase intraocular pressure in patients with certain types of eye inflammation. - **Severe bradycardia or heart block**: Due to its effects on the parasympathetic nervous system, Pilocarpine may exacerbate slow heart rates or conduction abnormalities, and it should not be used in such cases. - **Narrow-angle glaucoma**: This condition may worsen with the use of Pilocarpine, as its effects on the eye may increase the risk of acute angle-closure glaucoma.

Side Effect

Common side effects of Pilocarpine Hydrochloride include: - **Eye-related effects**: - Blurred vision or difficulty focusing, due to pupil constriction. - Eye irritation, redness, or discomfort. - **Systemic effects**: - **Increased sweating** (diaphoresis), which can be excessive. - **Nausea and vomiting**, due to its cholinergic effects on the gastrointestinal system. - **Headache** or dizziness. - **Abdominal cramping** or diarrhea, as Pilocarpine can increase gastrointestinal motility. - **Serious side effects** (although rare): - **Severe respiratory distress**, especially in patients with pre-existing lung conditions like asthma. - **Bradycardia or heart block**, which may result in fainting or dizziness. - **Severe allergic reactions**, including difficulty breathing, swelling of the face, lips, or throat, requiring immediate medical attention. Patients should contact their healthcare provider if they experience any unusual or severe side effects.

Pregnancy Category ID

3

Mode of Action

Pilocarpine works by stimulating the muscarinic receptors in the parasympathetic nervous system. Specifically, it acts as a **muscarinic cholinergic agonist**, which mimics the action of acetylcholine. By binding to muscarinic receptors, Pilocarpine: - **In the eye**: It increases the outflow of aqueous humor through the trabecular meshwork, reducing intraocular pressure in glaucoma patients. - **In the salivary glands**: It stimulates the production of saliva, helping to alleviate dry mouth conditions, such as those caused by Sjögren’s syndrome or radiation therapy. - **In the gastrointestinal system**: Pilocarpine increases motility and secretion in the gastrointestinal tract, which can be beneficial for patients with conditions like dry mouth but may lead to adverse gastrointestinal effects in others.

Interaction

Several drug interactions can occur with Pilocarpine Hydrochloride, including: - **Anticholinergics**: Drugs that block cholinergic activity, such as atropine, may reduce the effectiveness of Pilocarpine. - **Beta-blockers**: Concomitant use of Pilocarpine with beta-blockers may enhance the risk of bradycardia and hypotension. - **Parasympathomimetic agents**: Other cholinergic drugs (e.g., donepezil for Alzheimer's) may increase the effects of Pilocarpine and should be used with caution. - **Drugs that affect intraocular pressure**: Concurrent use with other medications to treat glaucoma may either potentiate or counteract the effects of Pilocarpine. - **Antihistamines and tricyclic antidepressants**: These medications may reduce the salivary flow, counteracting the effects of Pilocarpine in treating dry mouth. Patients should discuss all medications they are taking, including over-the-counter drugs and supplements, with their healthcare provider before starting Pilocarpine.

Pregnancy Category Note

Information not available

Adult Dose

The typical dosing for Pilocarpine varies based on its indication: - **For Glaucoma**: - **Topical**: 1–2 drops in the affected eye(s) 2–4 times per day. - **For Dry Mouth (Xerostomia)**: - **Oral tablets**: 5 mg, 3 to 4 times a day. If necessary, the dose can be increased to a maximum of 10 mg every 4–6 hours, depending on clinical response. The dose may need to be adjusted based on individual response and tolerance, with periodic monitoring for side effects such as excessive sweating or gastrointestinal discomfort.

Child Dose

Pilocarpine Hydrochloride is not typically used in pediatric populations for conditions like dry mouth, but for specific cases such as congenital glaucoma or when prescribed by a specialist: - **For Glaucoma**: - The dose depends on the child’s age and the severity of the condition, but typically 1–2 drops in the affected eye(s) 2–4 times a day is used. - **For Xerostomia** (rare pediatric use): - The typical pediatric dose is 2.5–5 mg orally, 3–4 times a day, adjusted based on the clinical response. As always, pediatric dosing should be determined by a healthcare provider, and careful monitoring is essential. It is paramount to consult a healthcare provider before initiating any medication, including Pilocarpine Hydrochloride, to ensure safety and proper treatment for the specific condition.

Renal Dose

Patients with **renal impairment** should use Pilocarpine with caution. Renal function does not significantly affect Pilocarpine’s pharmacokinetics, so dose adjustments are not generally required. However, because renal function affects drug clearance, patients with severe renal dysfunction may be more prone to side effects. Regular monitoring of kidney function and any adverse effects is essential in these cases.

Administration

Information not available