Elemental Iron (carbonyl iron) + Folic Acid

Welcome to Dwaey, specifically on Elemental Iron (carbonyl iron) + Folic Acid page.
This medicine contains important and useful components, as it consists of
Elemental Iron (carbonyl iron) + Folic Acid is available in the market in concentration.

Generic Name of Elemental Iron (carbonyl iron) + Folic Acid - Learn More

Elemental Iron (carbonyl iron) + Folic Acid Precaution - What You Need to Know

The combination of elemental iron (carbonyl iron) and folic acid is used to prevent or treat iron deficiency anemia and folate deficiency. This combination should be used with caution in certain populations, particularly those with a history of gastrointestinal disorders, such as peptic ulcers or inflammatory bowel disease, as iron supplements can irritate the gastrointestinal tract. Patients with hemochromatosis or other conditions resulting in iron overload should avoid this combination, as excess iron can accumulate and lead to organ damage.

In pregnant women, folic acid is crucial for fetal development, especially during the early stages of pregnancy. The recommended daily intake of folic acid during pregnancy is typically 400-800 mcg to prevent neural tube defects. However, iron supplementation may be required if the woman is found to have low iron levels, and this combination is often used during pregnancy. Pregnant women should use this combination under the guidance of a healthcare provider, as excessive iron intake can lead to complications, such as constipation or iron toxicity.

Patients with renal impairment or chronic kidney disease should be monitored closely while using this combination, as they may require dose adjustments, particularly with iron. Geriatric patients are also at an increased risk for iron overload, and extra caution should be exercised when prescribing iron supplements to older adults.

Elemental Iron (carbonyl iron) + Folic Acid Indication - Uses and Benefits

The combination of elemental iron (carbonyl iron) and folic acid is primarily indicated for the treatment of iron deficiency anemia and megaloblastic anemia due to folate deficiency. It is commonly used in cases of anemia during pregnancy, where both iron and folic acid are critical for maternal health and fetal development. Iron is essential for hemoglobin production, while folic acid is necessary for the synthesis of red blood cells and the prevention of neural tube defects in the fetus.

The combination can also be used in patients with iron deficiency resulting from poor diet, chronic blood loss (such as from gastrointestinal bleeding or heavy menstrual periods), or increased iron demand, such as in athletes or those recovering from surgery. Additionally, iron and folic acid supplementation may be prescribed for individuals with malabsorption syndromes or who have undergone gastric bypass surgery, where nutrient absorption is compromised.

Off-label uses may include the management of anemia in patients with chronic disease, particularly in those with chronic kidney disease or heart failure, where anemia is a common complication.

Elemental Iron (carbonyl iron) + Folic Acid Contraindications - Important Warnings

The combination of elemental iron (carbonyl iron) and folic acid is contraindicated in patients with a known hypersensitivity to any of its components. Iron overload conditions, such as hemochromatosis or thalassemia, are contraindications for the use of this combination, as excess iron can cause severe organ damage, particularly to the liver, heart, and pancreas.

The use of iron supplements is also contraindicated in anemia of non-iron-deficiency origin, such as hemolytic anemia or sickle cell disease, where iron supplementation would not address the underlying cause and could potentially lead to iron toxicity.

Patients with peptic ulcers, gastritis, or other active gastrointestinal disorders should avoid this combination unless recommended by a healthcare provider, as iron supplementation may exacerbate gastrointestinal irritation. Folic acid supplementation should be used cautiously in patients with vitamin B12 deficiency, as high folate levels can mask the symptoms of a B12 deficiency, leading to potential neurological damage if left untreated.

Elemental Iron (carbonyl iron) + Folic Acid Side Effects - What to Expect

Common side effects of iron (carbonyl iron) and folic acid include gastrointestinal disturbances such as nausea, constipation, diarrhea, and stomach discomfort. Iron supplementation is also associated with dark stools, which is harmless but can be alarming for patients.

More serious side effects may include iron toxicity, especially in children, which can lead to symptoms such as abdominal pain, vomiting, and diarrhea. In severe cases, iron toxicity can cause organ damage. The risk of iron toxicity can be minimized by ensuring the drug is kept out of reach of children.

Excessive doses of folic acid (greater than 1 mg/day) may cause sleep disturbances, irritability, and nervousness. Additionally, high doses of folic acid can mask the symptoms of vitamin B12 deficiency, leading to undiagnosed nerve damage.

Elemental Iron (carbonyl iron) + Folic Acid Mode of Action - How It Works

The combination of carbonyl iron and folic acid works synergistically to address deficiencies in both iron and folate, which are essential nutrients for the production of red blood cells and the maintenance of hematopoiesis (the formation of blood cells).

- Iron is necessary for the synthesis of hemoglobin, the protein in red blood cells that carries oxygen throughout the body. Iron is incorporated into the heme group of hemoglobin, and insufficient iron levels result in anemia.
- Folic acid is involved in the synthesis of DNA and RNA and is essential for cell division and the formation of red blood cells in the bone marrow. Folate deficiency leads to megaloblastic anemia, where the red blood cells are larger than normal and immature, leading to ineffective oxygen transport.

Elemental Iron (carbonyl iron) + Folic Acid Drug Interactions - What to Avoid

Several drug interactions may affect the efficacy or safety of elemental iron (carbonyl iron) and folic acid.

1. Iron absorption can be impaired by the presence of antacids, calcium supplements, phosphate binders, and tetracycline antibiotics, which should not be taken within 2 hours of taking iron supplements.
2. Iron can reduce the absorption of levothyroxine, a medication used for hypothyroidism. It is advised to separate the administration of these drugs by at least 4 hours.
3. Folic acid may reduce the effectiveness of methotrexate (a medication used to treat cancer and autoimmune diseases) by competing for the same metabolic pathways. Patients on methotrexate therapy should monitor folate intake.
4. Iron and folic acid can interfere with the effectiveness of some antibiotics (such as quinolone antibiotics), as they can bind to the medication, reducing its absorption.
5. Alcohol can interfere with iron absorption and contribute to iron deficiency anemia, so alcohol consumption should be limited during therapy.

Elemental Iron (carbonyl iron) + Folic Acid Adult Dose - Recommended Dosage

The typical adult dose for iron and folic acid supplementation is one tablet daily, although the specific dose may vary depending on the formulation and the severity of the deficiency. Iron (carbonyl iron) is generally administered at 50-100 mg/day, while folic acid is often provided at 400 mcg/day for general supplementation or higher doses for therapeutic purposes (e.g., 1 mg/day for folate deficiency).

Elemental Iron (carbonyl iron) + Folic Acid Child Dose - Dosage for Children

For children, the dosage of elemental iron (carbonyl iron) and folic acid varies based on age and the severity of the deficiency. For infants and young children, iron is typically dosed at 1–3 mg/kg/day, and folic acid may be given at 50–400 mcg/day, depending on the clinical condition.

In summary, elemental iron (carbonyl iron) combined with folic acid is an effective treatment for iron deficiency anemia and folate deficiency. It should be used with care in populations at risk of iron overload and in individuals with underlying gastrointestinal or liver disease. Regular monitoring of iron levels, liver function, and red blood cell indices is essential for optimal therapy.

Elemental Iron (carbonyl iron) + Folic Acid Renal Dose - Dosage for Kidney Conditions

In patients with renal impairment, no specific dose adjustment for folic acid is required, as it is water-soluble and excreted through the urine. However, for iron supplements, caution should be exercised in individuals with severe kidney disease, as iron overload can lead to organ toxicity, particularly in patients with end-stage renal disease.

Iron & Vitamin Combined preparations -