Risedronate Sodium (Risedronic acid)

Welcome to Dwaey, specifically on Risedronate Sodium (Risedronic acid) page.
This medicine contains important and useful components, as it consists of
Risedronate Sodium (Risedronic acid) is available in the market in concentration.

Generic Name of Risedronate Sodium (Risedronic acid) - Learn More

Risedronate Sodium (Risedronic acid)

Risedronate Sodium (Risedronic acid) Precaution - What You Need to Know

Before starting Risedronate Sodium (Risedronic acid), it is essential that patients consult their healthcare provider to ensure that this medication is appropriate for their condition. Key precautions to consider include:

- Esophageal Disorders: Risedronate can irritate the esophagus. Patients with esophageal abnormalities, such as strictures, achalasia, or a history of gastroesophageal reflux disease (GERD), should use it cautiously.
- Renal Impairment: Patients with severe renal impairment (creatinine clearance <30 mL/min) should not use Risedronate, as its safety in this population has not been established. Mild to moderate renal impairment may require dose adjustment.
- Bone, Joint, or Muscle Pain: Risedronate can cause musculoskeletal pain, and in rare cases, it has been associated with osteonecrosis of the jaw (ONJ), especially in cancer patients receiving chemotherapy or corticosteroids.
- Hypocalcemia: This medication can lower blood calcium levels, so it should be used cautiously in patients with low serum calcium levels. Hypocalcemia should be corrected before starting Risedronate.
- Pregnancy and Lactation: Risedronate is not recommended during pregnancy, as its safety has not been established. It is also not recommended for breastfeeding women unless deemed absolutely necessary by a healthcare provider.
- Dental Check-up: Prior to starting treatment, patients should have a dental check-up, as the risk of osteonecrosis of the jaw may be higher in those with existing dental issues or who require dental surgery.

Risedronate Sodium (Risedronic acid) Indication - Uses and Benefits

Risedronate Sodium (Risedronic acid) is primarily used to treat and prevent conditions related to bone loss and is commonly prescribed for:

- Osteoporosis: Risedronate is used to treat osteoporosis in postmenopausal women, helping to reduce the risk of fractures (vertebral, hip, etc.) by increasing bone density.
- Paget's Disease of Bone: Risedronate is also used to treat Paget's disease, a condition where the bone is abnormally broken down and rebuilt, leading to weakened bone.
- Glucocorticoid-induced Osteoporosis: It is indicated for the prevention and treatment of bone loss associated with long-term steroid therapy (glucocorticoids), which can cause osteoporosis.
- Male Osteoporosis: In men, Risedronate is indicated for the treatment of osteoporosis to reduce fracture risk.

Risedronate helps to increase bone mineral density and decrease the risk of fractures by inhibiting the activity of osteoclasts, the cells responsible for bone resorption.

Risedronate Sodium (Risedronic acid) Contraindications - Important Warnings

Risedronate Sodium is contraindicated in the following situations:

- Severe Hypocalcemia: It should not be used in patients with severe low calcium levels (hypocalcemia) because the drug can worsen this condition.
- Esophageal Disorders: Risedronate is contraindicated in individuals with esophageal abnormalities, such as stricture, achalasia, or active esophageal diseases (e.g., GERD), as it can cause irritation or ulcers.
- Severe Renal Impairment: It is contraindicated in patients with severe renal impairment, especially those with a creatinine clearance below 30 mL/min, because it is primarily excreted through the kidneys.
- Pregnancy: It is contraindicated during pregnancy, as there is insufficient evidence of safety and efficacy for pregnant women.
- Breastfeeding: Risedronate is not recommended for use while breastfeeding, as it is not known whether it is excreted in breast milk.
- Hypersensitivity: People who have had a previous allergic reaction to Risedronate or any of its ingredients should avoid using it.

Risedronate Sodium (Risedronic acid) Side Effects - What to Expect

While Risedronate is generally well-tolerated, some individuals may experience side effects, ranging from mild to severe. Common and serious side effects include:

- Common Side Effects:
- Gastrointestinal Issues: Abdominal pain, indigestion, acid reflux, nausea, and constipation are frequent.
- Musculoskeletal Pain: Patients may experience pain in muscles, joints, or bones.
- Headache: Some users report headaches during treatment.
- Back Pain: This can occur in the early stages of treatment.

- Serious Side Effects:
- Osteonecrosis of the Jaw (ONJ): A rare but severe condition where the jawbone becomes weakened or dies, often following dental procedures or trauma.
- Esophageal Ulcers: Risedronate can cause serious irritation or ulceration of the esophagus if it does not pass quickly through the esophagus. This is why it must be taken with a full glass of water and patients should remain upright for at least 30 minutes afterward.
- Hypocalcemia: Severe low blood calcium levels can occur, especially in patients with pre-existing low calcium.
- Severe Allergic Reactions: Symptoms like rash, hives, difficulty breathing, or swelling of the face and throat can occur in rare cases.

Patients should monitor for these side effects and report any concerning symptoms to their healthcare provider.

Risedronate Sodium (Risedronic acid) Pregnancy Category ID - Safety Information

3

Risedronate Sodium (Risedronic acid) Mode of Action - How It Works

Risedronate works as a bisphosphonate, a class of drugs that inhibit osteoclast activity, which are the cells responsible for breaking down bone tissue. Its mechanism of action is as follows:

- Inhibition of Bone Resorption: Risedronate binds to hydroxyapatite crystals in bone, inhibiting osteoclast-mediated bone resorption. This prevents the breakdown of bone tissue, which helps maintain bone density and strength.
- Increase in Bone Mineral Density: By inhibiting bone resorption, Risedronate allows for the increase of bone mineral density (BMD), which helps in the prevention of fractures, particularly in people with osteoporosis.
- Reduction of Fracture Risk: The decrease in bone resorption reduces the risk of fractures, particularly vertebral fractures, and hip fractures in patients with osteoporosis.
- Modification of Bone Turnover: The drug reduces the rate of bone turnover, creating a balance between bone formation and resorption that improves bone quality over time.

Risedronate Sodium (Risedronic acid) Drug Interactions - What to Avoid

Several drug interactions can influence the effectiveness or safety of Risedronate Sodium. These include:

- Calcium Supplements: Calcium supplements, antacids, and certain mineral supplements (especially those containing calcium, magnesium, or aluminum) can interfere with Risedronate’s absorption. It is advised to take Risedronate at least 30 minutes before consuming any food, drink, or other medications containing these minerals.
- Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Concomitant use of NSAIDs, such as ibuprofen or naproxen, may increase the risk of gastric irritation, ulcers, or gastrointestinal bleeding.
- H2 Antagonists and Proton Pump Inhibitors (PPIs): Medications that reduce stomach acid, such as ranitidine or omeprazole, may reduce the absorption of Risedronate. These should be used with caution and under supervision.
- Corticosteroids: Long-term use of corticosteroids can exacerbate osteoporosis and may reduce the effectiveness of Risedronate in preventing bone loss.
- Aminoglycoside Antibiotics: Aminoglycosides, like gentamicin, may increase the risk of kidney toxicity when used alongside Risedronate in some patients.

Risedronate Sodium (Risedronic acid) Adult Dose - Recommended Dosage

The usual dose of Risedronate for treating osteoporosis is:

- Osteoporosis: The standard dose is 35 mg once a week or 5 mg daily, depending on the patient’s preference and the physician's recommendation.
- Paget’s Disease of Bone: The dose for Paget’s disease is 30 mg daily for 2 months.
- Glucocorticoid-induced Osteoporosis: The typical dose is 5 mg daily.
- Male Osteoporosis: The dose is usually 35 mg weekly.

Risedronate should be taken on an empty stomach with a full glass of water at least 30 minutes before any food, drink, or other medications, and the patient should remain upright for at least 30 minutes after taking it.

Risedronate Sodium (Risedronic acid) Child Dose - Dosage for Children

Risedronate is not approved for use in children. The safety and efficacy of Risedronate have not been established in pediatric patients, and it is generally not recommended for those under 18 years of age.

Risedronate Sodium (Risedronic acid) Renal Dose - Dosage for Kidney Conditions

- Mild to Moderate Renal Impairment: No dose adjustment is typically required for patients with mild to moderate renal impairment (creatinine clearance >30 mL/min).
- Severe Renal Impairment: Risedronate is contraindicated in patients with severe renal impairment (creatinine clearance <30 mL/min), as its safety has not been established in this population.