Immune Serum Globulin Human

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Generic Name of Immune Serum Globulin Human - Learn More

Immune Serum Globulin Human

Immune Serum Globulin Human Precaution - What You Need to Know

Before receiving Immune Serum Globulin Human (ISGH), patients must consult their healthcare provider, especially if they have any pre-existing conditions. Key precautions include:

- Allergic Reactions: Patients with a history of allergies to immune globulin products or any component of the formulation should avoid using this medication. A severe allergic reaction (e.g., anaphylaxis) can occur in rare instances, so proper screening is essential.
- Pre-existing Conditions: Caution is needed for individuals with renal issues or kidney disease, as immune globulin products can affect kidney function. Kidney problems may be exacerbated, particularly in those receiving high doses or those with underlying risk factors.
- Thrombosis Risk: Immune serum globulin may increase the risk of blood clots, especially in individuals with a history of thrombosis or those who are immobilized for long periods. Monitoring for signs of deep vein thrombosis (DVT), pulmonary embolism, or stroke is advised.
- Pregnancy and Breastfeeding: While ISGH is generally considered safe during pregnancy, it should only be used when the potential benefits outweigh the risks. Pregnant women and breastfeeding mothers should seek medical advice before starting treatment.
- Pre-existing Immunodeficiencies: Individuals with a defective immune system, such as those with IgA deficiency, should use caution, as hypersensitivity reactions are more likely.

Immune Serum Globulin Human Indication - Uses and Benefits

Immune Serum Globulin Human is used for various medical conditions that involve immune system support. Indications include:

- Immunodeficiency Disorders: Used in individuals with primary or secondary immunodeficiencies, such as common variable immunodeficiency (CVID) or X-linked agammaglobulinemia, to boost immune function and prevent infections.
- Autoimmune Diseases: In conditions like immune thrombocytopenic purpura (ITP) or Guillain-Barré syndrome, ISGH can help modulate the immune system and reduce symptoms.
- Post-exposure Prophylaxis: Used for individuals who have been exposed to hepatitis A, hepatitis B, measles, or varicella to provide passive immunity and prevent disease development.
- Hematological Disorders: Used in patients with low platelet counts or certain blood disorders to restore immune function and protect against infection.
- Organ Transplantation: In transplant patients, ISGH helps to prevent rejection by providing necessary antibodies and supporting immune function post-transplant.

Immune Serum Globulin Human Contraindications - Important Warnings

Certain conditions or situations may make the use of Immune Serum Globulin Human inappropriate:

- Hypersensitivity: Contraindicated in individuals with known hypersensitivity to human immunoglobulin products or any of its ingredients. Anaphylactic reactions can occur.
- IgA Deficiency: Patients with a severe IgA deficiency are at risk of developing allergic reactions or anaphylaxis due to the presence of IgA in immune serum globulin. This product should be avoided in such cases unless the benefit outweighs the risk.
- Severe Renal Impairment: Immune serum globulin is not recommended for individuals with severe kidney disease or renal failure, as it can worsen renal function. If required, the dosage should be reduced, and close monitoring is essential.
- Hyperviscosity Syndrome: In patients with a predisposition to hyperviscosity, such as those with waldenström macroglobulinemia or multiple myeloma, the use of ISGH should be avoided due to the risk of thromboembolic events.
- Acute Intercurrent Infection: Individuals with an active infection may be at risk of complications when using immune serum globulin, and it is essential to treat the infection first before administering the drug.

Immune Serum Globulin Human Side Effects - What to Expect

While Immune Serum Globulin Human is generally well-tolerated, it may cause side effects. Common side effects include:

- Common Side Effects:
- Headache: A frequent side effect that can occur in 10-15% of patients.
- Fever: Mild fever or chills can occur as part of the body's immune response to the infusion.
- Injection Site Reactions: Pain, swelling, or redness at the injection site may occur.
- Fatigue: Some patients may feel tired or weak after administration.

- Severe Side Effects:
- Renal Failure: ISGH has been associated with acute renal failure, particularly in patients with pre-existing kidney issues. This is most common with high doses or rapid infusions.
- Anaphylaxis: Rare but serious, anaphylactic reactions (difficulty breathing, rash, swelling, etc.) can occur in some individuals. Immediate discontinuation of the product and emergency medical intervention are necessary.
- Thromboembolic Events: Patients may be at risk of deep vein thrombosis (DVT), pulmonary embolism (PE), or stroke, especially if they are immobilized or have a history of blood clots.
- Hemolysis: In rare cases, immune serum globulin can cause the breakdown of red blood cells, leading to anemia and jaundice.

Immune Serum Globulin Human Pregnancy Category ID - Safety Information

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Immune Serum Globulin Human Mode of Action - How It Works

Immune Serum Globulin Human (ISGH) works by providing passive immunity through the administration of a concentrated form of immunoglobulins (antibodies) derived from human plasma. The mechanism of action includes:

- Immune Support: The immunoglobulins (mainly IgG) in the serum provide immediate immune protection by neutralizing toxins, preventing infections, and enhancing phagocytosis by immune cells.
- Modulation of Immune Response: ISGH can help modulate immune system activity, especially in conditions where the immune system is underactive or overactive (e.g., autoimmune diseases, immunodeficiencies).
- Passive Immunity: When administered after exposure to certain infectious agents (e.g., hepatitis B, measles, varicella), ISGH provides passive immunity, thereby reducing the risk of developing the disease.
- Reduction of Inflammation: ISGH can also help in autoimmune diseases by reducing inflammatory responses, particularly in diseases like Guillain-Barré syndrome or ITP.

Immune Serum Globulin Human Drug Interactions - What to Avoid

Immune Serum Globulin Human may interact with other medications, altering its effectiveness or increasing the risk of side effects. Some interactions to be aware of include:

- Live Vaccines: ISGH can interfere with the immune response to live vaccines, such as measles, mumps, rubella, varicella, and yellow fever vaccines. Vaccination should be delayed for at least 3 months after receiving immune globulin therapy to ensure efficacy.
- Immunosuppressants: Concomitant use with immunosuppressive drugs (e.g., corticosteroids, chemotherapy agents) can alter the effectiveness of ISGH, possibly reducing its ability to enhance immunity. Dose adjustments or alternative therapies may be considered.
- Antiplatelet and Anticoagulant Drugs: Combining immune serum globulin with antiplatelet agents or anticoagulants may increase the risk of bleeding or thrombosis, especially in high doses. Close monitoring is required for patients on these medications.
- Vaccines: As mentioned, ISGH can affect the body's ability to produce an immune response to live vaccines. Patients should be advised to consult their healthcare provider before receiving any vaccines following the use of ISGH.

Immune Serum Globulin Human Adult Dose - Recommended Dosage

The dose of Immune Serum Globulin Human depends on the condition being treated. General guidelines include:

- Primary Immunodeficiency: 300-600 mg/kg every 3-4 weeks, depending on individual needs and response.
- Immune Thrombocytopenic Purpura (ITP): 1g/kg body weight for 1-2 days.
- Guillain-Barré Syndrome: 0.4 g/kg daily for 5 days.
- Post-exposure Prophylaxis: 0.6 mL/kg body weight (in cases of varicella, hepatitis B, etc.) given as a single dose.

Immune Serum Globulin Human Child Dose - Dosage for Children

Dosing for pediatric patients is typically based on weight and specific condition:

- Primary Immunodeficiency: 200-400 mg/kg every 3-4 weeks, with adjustments based on clinical response.
- Autoimmune Conditions (e.g., ITP, Guillain-Barré): Doses are typically higher, at 1g/kg for a short duration, often administered over 1-2 days.
- Post-exposure Prophylaxis: 0.6 mL/kg for pediatric patients exposed to infectious agents, such as hepatitis B or varicella.

As with adults, consultation with a healthcare provider is essential to determine the appropriate dose and ensure safe use for children.

Immune Serum Globulin Human Renal Dose - Dosage for Kidney Conditions

For patients with renal impairment, Immune Serum Globulin Human should be used cautiously. Dose adjustments may be necessary to minimize the risk of kidney damage, particularly in those with pre-existing renal disease or acute kidney injury. Reduced infusion rates or lower doses may be recommended.