OXAMI 20mg Tablets/Film-coated

What is OXAMI 20mg

OXAMI 20mg is a prescription antihypertensive medication that contains Olmesartan medoxomil as its active ingredient. It is formulated as film-coated tablets and typically comes in packs of 30 tablets (10s blister x 3).

• Classified as an angiotensin II receptor blocker (ARB).
• Primarily used to treat high blood pressure (hypertension).
• May be prescribed alone or in combination with other antihypertensive agents.
• Helps reduce the risk of cardiovascular complications such as stroke, heart attack, and kidney problems.
• Suitable for long-term use under regular medical supervision.

By controlling blood pressure effectively, OXAMI contributes to the protection of organs such as the heart, brain, and kidneys.

How to use OXAMI 20mg

OXAMI 20mg tablets should be taken exactly as prescribed by your healthcare provider. Adherence to the dosing schedule is key to achieving optimal therapeutic outcomes.

• Take one tablet orally, once daily, with or without food.
• Swallow the tablet whole with water—do not crush or chew.
• Try to take the dose at the same time each day for consistency.
• Do not stop taking the medication abruptly unless instructed by your doctor.
• It may take several weeks to experience the full benefits of treatment.
• Regular monitoring of blood pressure is advised to assess effectiveness.

If a dose is missed, take it as soon as remembered. If it's close to the next dose, skip the missed one. Do not double the dose. Avoid grapefruit juice unless cleared by your doctor, as it may affect drug metabolism.

Mode of Action OXAMI 20mg

Olmesartan medoxomil, the active ingredient in OXAMI 20mg, acts by selectively blocking angiotensin II type 1 receptors in the vascular smooth muscle.

• Angiotensin II is a potent vasoconstrictor that raises blood pressure by narrowing blood vessels.
• By blocking its receptors, Olmesartan promotes vasodilation (widening of blood vessels), thereby reducing blood pressure.
• Also reduces secretion of aldosterone, leading to decreased sodium and water retention.
• Does not inhibit the breakdown of bradykinin (unlike ACE inhibitors), making it less likely to cause a dry cough.

This targeted mechanism helps relax blood vessels, improves blood flow, and reduces the workload on the heart. The antihypertensive effect usually begins within one week and reaches maximum effect within 2–4 weeks of regular use.

OXAMI 20mg Interactions OXAMI 20mg

Drug interactions may affect how OXAMI works or increase the risk of side effects. Inform your healthcare provider of all medications, supplements, and herbal products you are using.

• Potassium supplements or potassium-sparing diuretics (e.g., spironolactone): May increase risk of hyperkalemia (high potassium).
• NSAIDs (e.g., ibuprofen, naproxen): May reduce the antihypertensive effect and increase risk of renal impairment.
• Diuretics: Enhanced blood pressure-lowering effect, but may increase risk of hypotension, especially after the first dose.
• Lithium: Risk of lithium toxicity may increase when co-administered with ARBs.
• Other antihypertensive agents (e.g., beta-blockers, calcium channel blockers): May have additive effects in lowering blood pressure.
• Alcohol: Can enhance the hypotensive effect of Olmesartan and lead to dizziness or fainting.

Periodic monitoring of serum potassium and renal function is recommended, especially in patients with underlying kidney disease or diabetes.

Dosage of OXAMI 20mg

The dosage of OXAMI 20mg is determined based on the patient’s blood pressure level, response to therapy, and other medical conditions.

• Initial dose: 20 mg once daily.
• Maintenance dose: May be increased to 40 mg once daily if further blood pressure reduction is needed after 2 weeks.
• Maximum dose: 40 mg/day.
• Elderly patients: No dosage adjustment usually required unless there is significant renal impairment.
• Renal impairment: Use with caution; no dosage adjustment required in mild to moderate impairment, but close monitoring is essential.
• Hepatic impairment: Start at the lower end of the dosing range.

Always follow the prescribed dose and never alter it without medical consultation. Regular checkups and lab tests may be required to evaluate kidney function and electrolyte balance.

Possible side effects of OXAMI 20mg

OXAMI 20mg is generally well-tolerated, but like all medications, it may cause side effects in some individuals.

• Common side effects:
  • Dizziness or lightheadedness (especially during initial dose)
  • Headache
  • Fatigue
  • Back pain
• Less common:
  • Upper respiratory infections
  • Gastrointestinal disturbances (nausea, diarrhea)
  • Increased blood potassium levels
• Rare but serious:
  • Severe hypotension (especially in volume-depleted patients)
  • Angioedema (swelling of face, lips, throat)
  • Kidney dysfunction or failure

If any unusual symptoms develop, especially difficulty breathing or swelling, immediate medical attention is required. Side effects are usually dose-dependent and reversible upon adjustment or discontinuation.

OXAMI 20mg Contraindications OXAMI 20mg

Use of OXAMI 20mg is contraindicated in certain populations and conditions due to safety concerns.

• Hypersensitivity to Olmesartan medoxomil or any of the tablet components.
• Pregnancy: Contraindicated in the second and third trimesters due to risk of fetal toxicity and death.
• Severe renal impairment or patients on dialysis—caution and specialist advice required.
• Bilateral renal artery stenosis: May lead to renal failure when using ARBs.
• History of angioedema related to previous ARB or ACE inhibitor use.

Before initiating therapy, a full medical history including cardiovascular, renal, and liver conditions should be evaluated to rule out contraindications.

Storage of OXAMI 20mg

Proper storage of OXAMI 20mg ensures the medication maintains its integrity and efficacy.

• Store at room temperature: 15°C to 30°C (59°F to 86°F).
• Protect from moisture and direct sunlight.
• Keep the tablets in their original blister packaging until use.
• Do not use after the expiry date mentioned on the carton or blister pack.
• Keep out of reach of children and pets.

Do not dispose of unused medicine in household waste. Consult a pharmacist about proper disposal to help protect the environment.