OXAMI H 40mg/12.5mg Tablets/Film-coated

What is OXAMI H 40mg/12.5mg

OXAMI H 40mg/12.5mg is a combination antihypertensive medication containing two active ingredients: Olmesartan medoxomil (40mg) and Hydrochlorothiazide (12.5mg). It is formulated as film-coated tablets designed to manage high blood pressure (hypertension) in patients who require more than one agent to achieve adequate blood pressure control.

• Olmesartan medoxomil is an angiotensin II receptor blocker (ARB) that works by relaxing blood vessels.
• Hydrochlorothiazide is a thiazide diuretic that helps eliminate excess salt and water from the body, lowering blood volume.
• The combination provides enhanced antihypertensive efficacy by targeting different mechanisms to reduce blood pressure, decreasing risks of cardiovascular events like stroke and heart attack.
• It is generally prescribed for patients whose blood pressure is not adequately controlled by monotherapy with either component.

How to use OXAMI H 40mg/12.5mg

To maximize the effectiveness of OXAMI H 40mg/12.5mg and minimize side effects, proper administration is important:

• Take one tablet orally once daily, with or without food.
• Swallow the tablet whole with water; do not crush or chew.
• Try to take the medication at the same time each day to maintain consistent blood levels.
• If a dose is missed, take it as soon as remembered unless it is close to the next scheduled dose; do not double doses.
• Continue therapy even if you feel well, as hypertension is often asymptomatic but requires continuous management.
• Regularly monitor blood pressure and kidney function as advised by your healthcare provider.
• Consult your doctor before stopping or changing the dose.

Mode of Action OXAMI H 40mg/12.5mg

The combination of Olmesartan medoxomil and Hydrochlorothiazide works through complementary mechanisms:

• Olmesartan medoxomil blocks the angiotensin II type 1 receptors on blood vessels, preventing angiotensin II from causing vasoconstriction (narrowing of blood vessels). This leads to vasodilation, reducing vascular resistance and lowering blood pressure.
• It also inhibits aldosterone release, which decreases sodium and water retention.
• Hydrochlorothiazide acts on the distal tubules of the kidneys to inhibit sodium and chloride reabsorption. This promotes increased excretion of sodium, chloride, and water, reducing blood volume and thereby lowering blood pressure.
• The diuretic effect helps to counteract the potassium-retaining effect of Olmesartan, balancing electrolyte levels.
• The combined effects result in improved blood pressure control compared to monotherapy with either agent alone.

OXAMI H 40mg/12.5mg Interactions OXAMI H 40mg/12.5mg

Several drug interactions should be considered when using OXAMI H 40mg/12.5mg, as they can influence safety and efficacy:

• Nonsteroidal anti-inflammatory drugs (NSAIDs): May reduce antihypertensive effects and increase risk of kidney impairment.
• Other antihypertensives: May potentiate hypotensive effects; blood pressure should be monitored closely.
• Potassium supplements or potassium-sparing diuretics: May increase risk of hyperkalemia, especially with Olmesartan.
• Lithium: Risk of lithium toxicity may increase; lithium levels should be monitored.
• Antidiabetic drugs: Hydrochlorothiazide may impair glucose tolerance and reduce insulin sensitivity.
• Cholestyramine or colestipol: May reduce absorption of hydrochlorothiazide.
• Drugs causing electrolyte imbalance (e.g., corticosteroids, amphotericin B): May exacerbate hypokalemia or other electrolyte disturbances.

Dosage of OXAMI H 40mg/12.5mg

The standard dosage regimen for OXAMI H 40mg/12.5mg is as follows:

• One tablet once daily, typically administered orally.
• Dosage may be adjusted by the healthcare provider based on blood pressure response and patient tolerance.
• It is usually prescribed for patients whose blood pressure is not adequately controlled with either Olmesartan or Hydrochlorothiazide alone.
• Maximum daily dose should not exceed the prescribed amount; do not self-adjust without medical advice.
• Patients with renal or hepatic impairment may require dosage adjustment or alternative therapy.
• Regular clinical monitoring is essential to assess effectiveness and safety.

Possible side effects of OXAMI H 40mg/12.5mg

Patients taking OXAMI H may experience side effects ranging from mild to severe. Common and important adverse effects include:

• Common: Dizziness, headache, fatigue, nausea, diarrhea, and muscle cramps.
• Electrolyte imbalances: Hypokalemia or hyperkalemia, hyponatremia, which may manifest as weakness, irregular heartbeat, or confusion.
• Hypotension: Excessive blood pressure lowering causing dizziness or fainting, especially in dehydrated patients.
• Renal impairment: Reduced kidney function, particularly in predisposed patients.
• Rare but serious: Allergic reactions such as rash, angioedema, or anaphylaxis; pancreatitis; gout flare-ups due to hyperuricemia.
• Inform your healthcare provider immediately if you experience swelling of the face, lips, or throat, severe skin reactions, or persistent muscle weakness.

OXAMI H 40mg/12.5mg Contraindications OXAMI H 40mg/12.5mg

OXAMI H 40mg/12.5mg should not be used in the following situations:

• Known hypersensitivity to Olmesartan, Hydrochlorothiazide, other sulfonamide-derived drugs, or any excipients in the formulation.
• Severe renal impairment or anuria.
• Severe hepatic impairment or cholestasis.
• Pregnancy, especially during the second and third trimesters, due to potential fetal toxicity.
• Patients with refractory hypokalemia or hypercalcemia.
• Use cautiously or avoid in patients with gout or significant electrolyte imbalance.

Storage of OXAMI H 40mg/12.5mg

Proper storage is essential to maintain the effectiveness and safety of OXAMI H 40mg/12.5mg:

• Store at room temperature below 30°C (86°F).
• Keep tablets in their original blister packaging until use to protect from moisture and light.
• Avoid storing in bathrooms or other humid places.
• Keep out of reach of children and pets to prevent accidental ingestion.
• Do not use the medication past the expiration date printed on the packaging.
• Dispose of unused or expired medication according to local regulations or pharmacy guidance.