OXAMI 40mg Tablets/Film-coated

What is OXAMI 40mg

OXAMI 40mg is a film-coated oral tablet that contains the active ingredient Olmesartan medoxomil, a long-acting angiotensin II receptor blocker (ARB). It is primarily used in the management of essential hypertension (high blood pressure), either alone or in combination with other antihypertensive agents. Controlling high blood pressure helps prevent strokes, heart attacks, and kidney issues.

• Drug class: Angiotensin II Receptor Blocker (ARB)
• Main use: Treatment of high blood pressure in adults and children over 6 years of age
• Secondary benefits: Renal protection in diabetic nephropathy (off-label use)
• Brand equivalence: OXAMI is a proprietary name for a generic formulation of olmesartan

This medicine works by selectively blocking the vasoconstrictor effects of angiotensin II, helping to relax blood vessels and lower blood pressure over time.

How to use OXAMI 40mg

OXAMI 40mg should be taken strictly according to your healthcare provider’s instructions. The tablet is for oral use and can be taken with or without food.

• Dosage timing: Take it once daily at the same time each day to maintain steady blood levels.
• Swallowing: Do not chew, crush, or split the tablet. Swallow it whole with water.
• Food interaction: Can be taken with or without meals, but consistent timing is advised.
• Missed dose: If a dose is missed, take it as soon as remembered. Skip if it’s close to the next dose—do not double up.
• Discontinuation: Do not stop taking the medication without consulting your doctor, as abrupt withdrawal may lead to rebound hypertension.

Regular blood pressure monitoring is essential to ensure the medicine is effectively controlling your condition.

Mode of Action OXAMI 40mg

Olmesartan medoxomil, the active compound in OXAMI 40mg, is a prodrug that becomes active once absorbed into the bloodstream. It blocks the binding of angiotensin II to its receptor (AT1 receptor) on the surface of vascular smooth muscle cells.

• Blocks angiotensin II effects: Prevents vasoconstriction, reducing vascular resistance and lowering blood pressure.
• Reduces aldosterone secretion: Promotes excretion of sodium and water, which helps lower blood volume and pressure.
• No effect on bradykinin: Unlike ACE inhibitors, it does not affect bradykinin metabolism, reducing the risk of cough or angioedema.
• Long duration of action: Its half-life allows for once-daily dosing, with effects sustained over 24 hours.

With consistent use, OXAMI helps protect the cardiovascular and renal systems by reducing the stress on blood vessels and organs caused by high blood pressure.

OXAMI 40mg Interactions OXAMI 40mg

Drug interactions may alter the effect of OXAMI 40mg or increase the risk of side effects. Always inform your healthcare provider about any medications, supplements, or herbal products you are using.

• NSAIDs (e.g., ibuprofen, naproxen): Can reduce the blood pressure-lowering effect and increase the risk of kidney damage.
• Potassium supplements and potassium-sparing diuretics: May lead to hyperkalemia (high potassium levels).
• Diuretics (e.g., furosemide): Can amplify the hypotensive effects, especially during initial dosing.
• Lithium: Increased risk of lithium toxicity when used concurrently; monitor serum lithium levels regularly.
• Aliskiren: Concomitant use is not recommended in diabetic or renal-impaired patients due to increased risk of renal dysfunction and hyperkalemia.
• Alcohol: May increase the risk of dizziness or lightheadedness by enhancing hypotensive effects.

Routine lab monitoring and clinical assessments may be required when using OXAMI alongside other medications.

Dosage of OXAMI 40mg

The dosage of OXAMI 40mg should be personalized based on clinical need, age, and concurrent health conditions. OXAMI 40mg is typically used when a lower dose (e.g., 20mg) has not adequately controlled blood pressure.

• Adults: 20mg once daily initially; may increase to 40mg once daily if needed.
• Maximum dose: 40mg once daily; higher doses do not show additional benefit and may increase risk of adverse effects.
• Children (≥6 years): Dose based on body weight and medical advice; should not exceed 40mg daily.
• Renal impairment: Caution is advised; dose adjustments may be necessary in severe impairment.
• Hepatic impairment: Use cautiously; dose adjustments may be required in moderate to severe liver disease.

Always follow your healthcare provider’s dosage recommendations and do not self-adjust the dose without consulting a professional.

Possible side effects of OXAMI 40mg

OXAMI 40mg is generally well tolerated, but like all medications, it may cause side effects in some individuals. The severity and likelihood can vary based on the dose and individual health status.

• Common side effects:
  • Dizziness or lightheadedness, especially when standing up quickly
  • Headache
  • Fatigue or weakness
• Less common side effects:
  • Gastrointestinal discomfort, including nausea or diarrhea
  • Back pain
  • Upper respiratory tract infections
• Serious side effects (rare):
  • Hyperkalemia (symptoms may include muscle weakness, irregular heartbeat)
  • Acute kidney injury
  • Angioedema (swelling of lips, tongue, or throat)
  • Severe hypotension

Report any severe or persistent side effects to a healthcare provider immediately. In cases of allergic reaction, seek emergency care.

OXAMI 40mg Contraindications OXAMI 40mg

OXAMI 40mg is not suitable for everyone. Its use is contraindicated in specific medical situations due to potential risks or lack of safety data.

• Hypersensitivity: Allergy to olmesartan medoxomil or any of the inactive ingredients in the tablet.
• Pregnancy: Especially contraindicated during the second and third trimesters due to the risk of fetal injury or death.
• Severe renal impairment: Especially in combination with potassium-elevating agents or dual renin-angiotensin system blockers.
• Severe hepatic impairment: Use is not recommended due to limited data and altered drug metabolism.
• Bilateral renal artery stenosis: May worsen kidney function.

Screening for these conditions before initiating therapy is essential to ensure safe use.

Storage of OXAMI 40mg

Proper storage helps maintain the stability and effectiveness of OXAMI 40mg tablets.

• Temperature: Store below 25°C (77°F). Avoid excessive heat or freezing temperatures.
• Humidity: Keep in a dry place. Avoid storage in bathrooms or kitchens where humidity is high.
• Light exposure: Store in the original blister packaging to protect from light and moisture.
• Keep out of reach: Ensure the medication is inaccessible to children and pets.
• Expiry: Do not use after the expiration date printed on the blister or carton.

Do not dispose of unused tablets in household trash or toilets. Ask a pharmacist for proper medication disposal options.