OXAMI H 20mg/12.5mg Tablets/Film-coated

What is OXAMI H 20mg/12.5mg

OXAMI H 20mg/12.5mg is a prescription medication that combines two active ingredients: Olmesartan medoxomil, an angiotensin II receptor blocker (ARB), and Hydrochlorothiazide, a thiazide diuretic (water pill). It is used primarily for the treatment of essential hypertension (high blood pressure) when monotherapy is not sufficient.

• Olmesartan medoxomil helps relax blood vessels by blocking the action of angiotensin II, a hormone that narrows blood vessels.
• Hydrochlorothiazide reduces excess fluid in the body by promoting the elimination of sodium and water through the urine.
• Combined, they offer enhanced blood pressure control and help prevent complications such as stroke, heart attacks, and kidney problems.

How to use OXAMI H 20mg/12.5mg

Always follow your healthcare provider’s instructions when taking OXAMI H. It is typically taken orally once daily, with or without food.

• Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
• Take the medicine at the same time each day to maintain consistent blood levels.
• If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double the dose.
• Continue taking the medication even if you feel well, as hypertension often has no noticeable symptoms.
• Regular monitoring of blood pressure, kidney function, and electrolytes (especially potassium) is important.

Mode of Action OXAMI H 20mg/12.5mg

The dual components of OXAMI H act synergistically to control blood pressure:

• Olmesartan medoxomil is converted to its active form in the gastrointestinal tract and blocks the angiotensin II receptor type 1 (AT1). This action prevents vasoconstriction and reduces aldosterone secretion, resulting in lower blood pressure.
• Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the nephron. This leads to increased excretion of sodium, chloride, and water, reducing plasma volume and thus lowering blood pressure.
• The combination allows for a greater antihypertensive effect than either component alone, and may also help mitigate potassium retention caused by olmesartan with the potassium-wasting effect of hydrochlorothiazide.

OXAMI H 20mg/12.5mg Interactions OXAMI H 20mg/12.5mg

OXAMI H can interact with a variety of medications, potentially increasing side effects or reducing efficacy:

• NSAIDs (e.g., ibuprofen, naproxen): May reduce the antihypertensive effect and increase the risk of kidney damage.
• Other antihypertensives: May enhance the blood pressure-lowering effect, increasing the risk of hypotension.
• Potassium supplements or potassium-sparing diuretics: May increase the risk of hyperkalemia (high potassium levels).
• Antidiabetic medications: Hydrochlorothiazide may impair glucose tolerance and reduce the effectiveness of insulin or oral hypoglycemics.
• Lithium: Concomitant use may increase lithium toxicity.
• Cholestyramine or colestipol: May reduce the absorption of hydrochlorothiazide.

Dosage of OXAMI H 20mg/12.5mg

The typical dose of OXAMI H 20mg/12.5mg is one tablet taken once daily. Dosage may be adjusted by a healthcare provider depending on individual blood pressure response and patient tolerance.

• Initial dose: Usually one tablet (20mg/12.5mg) per day.
• Maximum dose: Can be titrated to higher strengths (e.g., 40mg/25mg) if necessary.
• Adjustment: Required in elderly patients or those with renal or hepatic impairment.
• Monitoring: Blood pressure, electrolytes, and kidney function should be regularly monitored to avoid complications.
• This medication should not be used as initial therapy; it is indicated for patients whose blood pressure is not adequately controlled with monotherapy.

Possible side effects of OXAMI H 20mg/12.5mg

Like all medications, OXAMI H may cause side effects. While many are mild and manageable, some may require medical attention.

• Common side effects:
  • Dizziness
  • Headache
  • Fatigue
  • Gastrointestinal disturbances (nausea, diarrhea)
  • Muscle cramps
• Less common but serious:
  • Hypotension, especially in volume-depleted individuals
  • Electrolyte imbalances (low potassium, low sodium)
  • Impaired kidney function
  • Photosensitivity
• Rare side effects:
  • Allergic reactions including rash, pruritus, or angioedema
  • Hyperuricemia or gout
  • Sexual dysfunction

OXAMI H 20mg/12.5mg Contraindications OXAMI H 20mg/12.5mg

OXAMI H should not be used in certain patients due to the risk of serious adverse outcomes.

• Hypersensitivity: To olmesartan, hydrochlorothiazide, sulfonamide-derived drugs, or any excipients in the formulation.
• Severe renal impairment: Or patients with anuria (lack of urine production).
• Severe hepatic impairment: Or biliary obstruction.
• Pregnancy: Especially during the second and third trimesters, due to fetal toxicity risk.
• Hypercalcemia or hyponatremia: Pre-existing electrolyte imbalances should be corrected before starting treatment.
• Refractory hypokalemia: Risk of worsening the condition.

Storage of OXAMI H 20mg/12.5mg

Proper storage of OXAMI H ensures the medication remains effective and safe to use.

• Store below 30°C (86°F) in a dry place away from direct sunlight and moisture.
• Keep in the original packaging to protect from light and humidity.
• Keep out of reach of children and pets to avoid accidental ingestion.
• Do not use the medicine after the expiry date indicated on the packaging.
• Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to properly dispose of unused medicines.