LIPODAR 80 Tablets/Film-coated

What is LIPODAR 80

LIPODAR 80 is a high-strength lipid-lowering medication that contains 80 mg of Atorvastatin. It belongs to a class of drugs known as statins (HMG-CoA reductase inhibitors). This medication is used in adults who require substantial reductions in cholesterol, particularly low-density lipoprotein cholesterol (LDL-C), often due to significant cardiovascular risk or familial hypercholesterolemia. LIPODAR 80 is one of the highest available doses of Atorvastatin and is usually prescribed when lower doses have not achieved the desired cholesterol targets. The primary goal of therapy is to reduce cardiovascular events, improve lipid profiles, and slow the progression of atherosclerosis.

• Class: Statin / Lipid-lowering agent
• Indicated for: Hypercholesterolemia, cardiovascular disease prevention
• Special use: Patients with high cardiovascular risk and severe dyslipidemia
• Therapeutic benefit: Reduction in LDL-C by up to 55-60% in some patients

How to use LIPODAR 80

LIPODAR 80 is taken once daily. The tablet should be swallowed whole with water, with or without food. Consistency in timing helps optimize its effectiveness.

• Take at the same time each day, preferably in the evening
• Do not split or crush the tablet
• Adhere to a low-fat, cholesterol-controlled diet during treatment
• Avoid skipping doses; consult your doctor before stopping therapy
• Periodic liver function and cholesterol testing are recommended

Mode of Action LIPODAR 80

Atorvastatin works by selectively inhibiting HMG-CoA reductase, the key enzyme in the liver responsible for cholesterol production. This leads to:

• Decreased cholesterol synthesis in the liver
• Increased LDL receptor expression and uptake of circulating LDL-C
• Reduction of total cholesterol, LDL-C, apolipoprotein B, and triglycerides
• Mild to moderate increase in high-density lipoprotein cholesterol (HDL-C)

LIPODAR 80 Interactions LIPODAR 80

Care should be taken when using LIPODAR 80 with other drugs due to potential interactions.

• Macrolide antibiotics (e.g., clarithromycin): May raise statin levels, increasing risk of muscle toxicity
• Antifungals (e.g., itraconazole): Can inhibit statin metabolism
• Protease inhibitors: Increase plasma Atorvastatin levels significantly
• Grapefruit juice: Large amounts may increase risk of side effects
• Digoxin or oral contraceptives: May increase plasma levels of these medications

Dosage of LIPODAR 80

• Prescribed for patients requiring intensive lipid-lowering therapy
• Not typically used as an initial dose unless clinically justified
• Patients are often titrated up from 10 mg or 20 mg based on cholesterol response
• Should be used under close medical supervision

Possible side effects of LIPODAR 80

Although well tolerated in most cases, high-dose Atorvastatin may lead to side effects:

• Common: Headache, joint or muscle pain, diarrhea
• Less common: Liver enzyme elevation, insomnia, rash
• Serious but rare: Rhabdomyolysis, liver failure, allergic reactions
• Symptoms to watch for: Persistent muscle pain, weakness, dark urine, or yellowing of the skin/eyes

LIPODAR 80 Contraindications LIPODAR 80

• Active liver disease or persistent unexplained liver enzyme elevation
• Hypersensitivity to Atorvastatin or any component of the tablet
• Pregnancy (Category X) and breastfeeding
• Patients with severe renal impairment (use caution)

Storage of LIPODAR 80

• Store at room temperature, below 30°C
• Keep in the original blister packaging to protect from moisture
• Do not store in humid areas like bathrooms
• Keep out of reach of children
• Check expiry date before use