ACINIL 200mg Tablets

What is ACINIL 200mg

Composition: Acetic Acid (Glacial): Serves as the acidifying agent. Calcium Chloride Dihydrate: Provides calcium ions. Glucose Monohydrate: Supplies glucose. Magnesium Chloride Hexahydrate: Provides magnesium ions. Potassium Chloride: Supplies potassium ions. Sodium Chloride: Provides sodium and chloride ions. PMC +8 Wiley Online Library +8 metrohm.com +8 Function: This concentrate is designed to be mixed with a bicarbonate solution and purified water using a dialysis machine's proportioning system. The resulting dialysate mimics the electrolyte composition of normal plasma, aiding in the correction of metabolic imbalances during hemodialysis.

How to use ACINIL 200mg

Preparation: Mixing: Use a three-stream proportioning system to combine the acid concentrate with a bicarbonate concentrate and purified water. Proportioning Ratios: Common ratios include 1:1.72:42.28 (acid:base:water). Water Quality: Ensure water meets standards for hemodialysis, with a bacteriological colony count of <100 CFU/mL. PMC +5 PMC +5 Wiley Online Library +5 pharma-china.en.made-in-china.com +2 PMC +2 pmarketresearch.com +2 Administration: Dosage: Typically, 5 liters of concentrate per dialysis session, as prescribed by a physician. Monitoring: Regularly check the final dialysate's conductivity and pH to ensure correct composition. PubMed +2 Medex +2 pmarketresearch.com +2 pmarketresearch.com Precautions: Do Not Use Alone: The acid concentrate should not be used without proper mixing with bicarbonate concentrate and water. Visual Inspection: Discard if the solution appears discolored or contains particulates.

Mode of Action ACINIL 200mg

The acid concentrate contributes to the final dialysate solution used in hemodialysis. Its components serve the following purposes: PMC +4 PMC +4 Wiley Online Library +4 Acetic Acid: After entering the bloodstream, acetic acid is metabolized to bicarbonate via the citric acid cycle, aiding in buffering blood pH. Electrolytes (Calcium, Magnesium, Potassium, Sodium): Help maintain electrolyte balance, nerve function, and muscle contraction during dialysis. Glucose: Provides energy and prevents hypoglycemia during treatment. PMC By combining with bicarbonate concentrate and water, the resulting dialysate facilitates the removal of waste products and excess fluids from the blood, correcting metabolic imbalances in patients with kidney failure.

ACINIL 200mg Interactions ACINIL 200mg

While the acid concentrate itself is not directly involved in drug interactions, the components of the final dialysate solution can influence the pharmacokinetics of certain medications: Electrolyte Levels: Altered levels of potassium, calcium, and magnesium can affect the action of drugs like digoxin and antiarrhythmics. Acid-Base Balance: Changes in blood pH can influence the ionization and, consequently, the absorption and efficacy of certain medications. Precautions: Medication Review: Healthcare providers should review all patient medications to adjust dosages as necessary during dialysis. Monitoring: Regular monitoring of electrolyte levels and acid-base status is essential to prevent adverse drug effects.

Dosage of ACINIL 200mg

Standard Dosage: Volume: Typically, 5 liters of acid concentrate per dialysis session. Frequency: Used in each hemodialysis session, usually three times per week. Customization: Dosage may be adjusted based on patient-specific needs, including electrolyte imbalances and acid-base status. Medex Administration: Mixing: Use with a bicarbonate concentrate and purified water in a dialysis machine's proportioning system. Monitoring: Ensure the final dialysate has the correct electrolyte composition and pH before administration. Wiley Online Library +5 pharma-china.en.made-in-china.com +5 pmarketresearch.com +5 pmarketresearch.com +1 PMC +1 Note: Dosage adjustments should be made by a healthcare professional based on individual patient assessments.

Possible side effects of ACINIL 200mg

While the acid concentrate is generally well-tolerated, potential side effects related to its use in hemodialysis include: pmarketresearch.com Electrolyte Imbalances: Hypokalemia, hyperkalemia, hypocalcemia, or hypercalcemia, depending on the dialysate composition. Hypotension: Due to rapid fluid removal or vasodilation effects of acetate. Muscle Cramps: Often related to fluid and electrolyte shifts during dialysis. Nausea and Headache: Possibly associated with acetate metabolism. Management: Monitoring: Regular assessment of vital signs and electrolyte levels during dialysis sessions. Adjustments: Modifying dialysate composition or dialysis parameters as needed to mitigate side effects.

ACINIL 200mg Contraindications ACINIL 200mg

Use of this acid concentrate is contraindicated in the following situations: Hypersensitivity: Known allergy to any component of the concentrate. Severe Hypokalemia or Hyperkalemia: Depending on the potassium concentration in the final dialysate. Uncontrolled Coagulation Disorders: As rapid shifts in electrolytes can exacerbate bleeding risks. pharma-china.en.made-in-china.com Precautions: Patient Assessment: Thorough evaluation of electrolyte levels and coagulation status before initiating dialysis. Customized Dialysate: Adjusting the composition of the dialysate to meet individual patient needs and avoid contraindicated conditions.

Storage of ACINIL 200mg

Storage Conditions: Temperature: Store at room temperature, avoiding freezing. Environment: Keep in a well-ventilated area, away from direct sunlight and sources of contamination. Container Integrity: Ensure containers are sealed properly and inspect for any signs of damage or contamination before use. pharma-china.en.made-in-china.com Shelf Life: Duration: Typically, 12 months from the date of manufacture. Labeling: Always check the expiration date and adhere to manufacturer guidelines. Handling: Mixing: Use only with compatible bicarbonate concentrates and dialysis machines. Disposal: Follow local regulations for the disposal of medical solutions and containers.