DEXILANT 30mg Capsules (Hard Gelatin)/Modified Release

What is DEXILANT 30mg

DEXILANT 30mg (Dexlansoprazole) is a proton pump inhibitor (PPI) designed to reduce the amount of acid produced in the stomach. It is primarily indicated for the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, and heartburn associated with acid reflux. DEXILANT features a unique dual delayed-release formulation that allows two separate releases of medication, providing extended acid suppression over 24 hours.

• Generic Name: Dexlansoprazole
• Form: Hard Gelatin Capsules (Modified Release)
• Strength: 30 mg
• Package: 14 capsules (7s blister x 2)
• Primary Use: Treatment of GERD, healing of erosive esophagitis, and maintenance therapy for acid-related disorders.

Its innovative delivery system makes DEXILANT particularly effective for patients needing consistent, around-the-clock acid control.

How to use DEXILANT 30mg

Correct administration of DEXILANT ensures optimal therapeutic effects:

• Timing: Take the capsule at least 30 minutes before a meal, usually once daily unless otherwise directed.
• Swallowing: Swallow the capsule whole with water. Do not crush or chew the capsule, as this may destroy the delayed-release mechanism.
• Alternative Administration: If unable to swallow whole, the capsule can be opened, and the contents sprinkled onto a tablespoon of applesauce. Swallow the mixture immediately without chewing.
• Consistency: Take DEXILANT at the same time each day for the best results.

Adhering strictly to your doctor's instructions is crucial. Do not adjust the dose or discontinue use without consulting your healthcare provider.

Mode of Action DEXILANT 30mg

DEXILANT works through a specific mechanism targeting gastric acid production:

• Proton Pump Inhibition: Dexlansoprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme system at the surface of gastric parietal cells, effectively blocking the final step of acid production in the stomach.
• Dual Delayed-Release Technology: The capsule contains two types of enteric-coated granules that release at different times—one in the upper small intestine and the other in the lower small intestine—extending the duration of acid suppression.
• Extended Relief: This dual mechanism helps maintain a more stable pH in the stomach over a 24-hour period, improving healing rates and symptom control.

DEXILANT’s advanced delivery system sets it apart from traditional PPIs, offering longer protection and symptom relief even for patients with challenging acid-related disorders.

DEXILANT 30mg Interactions DEXILANT 30mg

Several drug interactions may occur with DEXILANT:

• Antifungals: Drugs like ketoconazole and itraconazole may have reduced absorption due to decreased stomach acid levels.
• Antivirals: Certain antivirals (e.g., atazanavir, nelfinavir) may be less effective when used with DEXILANT.
• Clopidogrel: Dexlansoprazole may reduce the activation of clopidogrel, a blood thinner, potentially decreasing its effectiveness.
• Warfarin: Concomitant use may increase the risk of bleeding; monitoring INR levels is advised.
• Digoxin: Increased absorption of digoxin may occur, raising toxicity risks.

Always inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting DEXILANT.

Dosage of DEXILANT 30mg

The recommended dosage regimen typically follows:

• GERD (Non-Erosive): 30 mg once daily for up to 4 weeks.
• Erosive Esophagitis: Healing phase: 60 mg once daily for up to 8 weeks; Maintenance therapy: 30 mg once daily.
• Special Populations: Dosage adjustments are generally not required in renal impairment, but caution is advised in severe hepatic impairment.
• Missed Dose: If a dose is missed, take it as soon as possible. If it’s near the time for the next dose, skip the missed dose—do not double dose.

Follow your prescribing physician’s specific dosing instructions, as the duration and need for treatment may vary based on individual conditions.

Possible side effects of DEXILANT 30mg

While generally well-tolerated, DEXILANT may cause some side effects:

• Common Side Effects: Diarrhea, abdominal pain, nausea, vomiting, flatulence.
• Less Common Effects: Headache, upper respiratory tract infections, and cough.
• Serious Side Effects:
  • Clostridium difficile infection (severe diarrhea)
  • Low magnesium levels (manifested as muscle cramps, seizures, or arrhythmias)
  • Bone fractures (long-term use)
  • Vitamin B12 deficiency (with prolonged use)

Seek immediate medical attention if symptoms of an allergic reaction (rash, swelling, difficulty breathing) occur.

DEXILANT 30mg Contraindications DEXILANT 30mg

Use of DEXILANT is contraindicated in:

• Allergy: Patients with known hypersensitivity to dexlansoprazole, other PPIs, or any ingredients of the formulation.
• Concomitant Use with Rilpivirine: This combination is contraindicated due to significant reductions in rilpivirine plasma concentrations, potentially leading to therapeutic failure.

Caution is warranted in individuals with a history of osteoporosis, vitamin B12 deficiency, or hypomagnesemia, especially with long-term therapy.

Storage of DEXILANT 30mg

Proper storage conditions help maintain the integrity and efficacy of DEXILANT:

• Temperature: Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Protect from Light and Moisture: Keep the capsules in their original blister packaging until use.
• Keep Out of Reach of Children: To prevent accidental ingestion.
• Do Not Use: After the expiration date indicated on the packaging.

Do not expose the medication to extreme temperatures or humidity. If in doubt about the integrity of the capsules, consult your pharmacist.