ANAFRANIL S.R 75mg price in UAE

Overview

Welcome to Dwaey, specifically on ANAFRANIL S.R 75mg Tablets/Divitabs page.
This medicine contains an important and useful components, as it consists of Clomipramine HCl.
ANAFRANIL S.R 75mg is available in the market in concentration 75mg/Tablet and in the form of Tablets/Divitabs.

NOVARTIS PHARMA AG is the producer of ANAFRANIL S.R 75mg and it is imported from SWITZERLAND, The most popular alternatives of ANAFRANIL S.R 75mg are listed downward .

Mode Of Action

Clomipramine is a potent inhibitor of serotonin re-uptake in the brain. Significant antagonism at cholinergic and ?1-receptors. Weak antagonism at dopamine receptors. It has also antidepressant, sedative and anticholinergic effects.

Indication

Depression
Panic disorder
Obsessive compulsive disorder
Cataplexy
Narcolepsy
Phobias
Premature ejaculation
Enuresis
Trichotillomania

Precaution

Cardiovascular insufficiency; narrow-angle glaucoma; urinary retention; history of epilepsy; renal or hepatic dysfunction; electroconvulsive therapy; hypotension; hyperthyroidism or concomitant treatment with thyroid preparations; suicidal tendencies; surgery; pregnancy and lactation; tasks requiring mental alertness; elderly; avoid abrupt withdrawal. Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)

Side Effects

>10% Xerostomia (84%)
Headache (50-55%)
Constipation (47%)
Ejaculation failure (42%)
Fatigue (35-40%)
Nausea (30-35%)
Impotence (20-25%)
Weight gain (18%) 1-10% Weight loss (5%)
Hepatotoxicity (1-3%) Frequency Not Defined Common
Dizziness
mainia
somnolence
tremor
Dyspepsia
Blurred vision
Urinary retention
Orgasm incapacity
libido change Potentially Fatal: Death
rare (except in patients with preexisting significant heart block and patients on MAOI therapy). Induction of mania in individuals with underlying manic-depressive illness or worsening of psychoses in already psychotic individuals.

Contra indication

Hypersensitivity. Concomitant use of MAOIs; recovery phase following MI, heartblock or other arrhythmias; mania; childn.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Interaction

Barbiturates increase metabolism of tricyclic antidepressants; conversely cimetidine, guanethidine, haloperidol and phenothiazines block the tricyclic metabolism. CNS effects of alcohol enhanced. Potentially Fatal: If clomipramine is to be substituted for MAOIs, at least 3 wk should elapse after discontinuing MAOIs. Risk of hypertension and arrhythmias if co-administered with adrenaline and noradrenaline.