ANAFRANIL 10mg price in UAE

Overview

Welcome to Dwaey, specifically on ANAFRANIL 10mg Tablets page.
This medicine contains an important and useful components, as it consists of Clomipramine HCl.
ANAFRANIL 10mg is available in the market in concentration 10mg/Tablet and in the form of Tablets.

NOVARTIS PHARMA AG is the producer of ANAFRANIL 10mg and it is imported from SWITZERLAND, The most popular alternatives of ANAFRANIL 10mg are listed downward .

Mode Of Action

Clomipramine is a potent inhibitor of serotonin re-uptake in the brain. Significant antagonism at cholinergic and ?1-receptors. Weak antagonism at dopamine receptors. It has also antidepressant, sedative and anticholinergic effects.

Indication

Depression
Panic disorder
Obsessive compulsive disorder
Cataplexy
Narcolepsy
Phobias
Premature ejaculation
Enuresis
Trichotillomania

Precaution

Cardiovascular insufficiency; narrow-angle glaucoma; urinary retention; history of epilepsy; renal or hepatic dysfunction; electroconvulsive therapy; hypotension; hyperthyroidism or concomitant treatment with thyroid preparations; suicidal tendencies; surgery; pregnancy and lactation; tasks requiring mental alertness; elderly; avoid abrupt withdrawal. Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)

Side Effects

>10% Xerostomia (84%)
Headache (50-55%)
Constipation (47%)
Ejaculation failure (42%)
Fatigue (35-40%)
Nausea (30-35%)
Impotence (20-25%)
Weight gain (18%) 1-10% Weight loss (5%)
Hepatotoxicity (1-3%) Frequency Not Defined Common
Dizziness
mainia
somnolence
tremor
Dyspepsia
Blurred vision
Urinary retention
Orgasm incapacity
libido change Potentially Fatal: Death
rare (except in patients with preexisting significant heart block and patients on MAOI therapy). Induction of mania in individuals with underlying manic-depressive illness or worsening of psychoses in already psychotic individuals.

Contra indication

Hypersensitivity. Concomitant use of MAOIs; recovery phase following MI, heartblock or other arrhythmias; mania; childn.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Interaction

Barbiturates increase metabolism of tricyclic antidepressants; conversely cimetidine, guanethidine, haloperidol and phenothiazines block the tricyclic metabolism. CNS effects of alcohol enhanced. Potentially Fatal: If clomipramine is to be substituted for MAOIs, at least 3 wk should elapse after discontinuing MAOIs. Risk of hypertension and arrhythmias if co-administered with adrenaline and noradrenaline.