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Overview

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This medicine contains an important and useful components, as it consists of
Benzocaine, Triclosanis available in the market in concentration

Name

Oxygenium

Precaution

Before using **Oxygenium**, it is essential for patients to consult with their healthcare provider, especially when using oxygen therapy in specific health contexts. Some key precautions include: - **Chronic Respiratory Conditions**: Patients with **Chronic Obstructive Pulmonary Disease (COPD)**, **emphysema**, or other chronic lung diseases should use oxygen therapy under close supervision. Overuse can lead to **carbon dioxide retention**, which can worsen respiratory acidosis. Oxygen therapy should be tailored to individual needs and should only be prescribed by a healthcare professional who understands the patient’s respiratory condition. - **Risk of Fire and Explosion**: **Oxygenium** is a highly flammable substance, and its use must be handled with caution to prevent accidental fires. Smoking or exposure to any **open flames**, **sparks**, or **flammable gases** in the vicinity of oxygen use can cause severe fires or explosions. - **Skin and Mucous Membrane Sensitivity**: Prolonged exposure to concentrated oxygen can lead to **dryness**, **irritation**, or **chemical burns** to the skin or mucous membranes (such as the nose and mouth) when delivered through devices like nasal cannulas or masks. - **Pregnancy**: Oxygen therapy is generally considered safe during pregnancy when prescribed and monitored by a healthcare provider. However, oxygen saturation and concentration should be carefully regulated to ensure the safety of both the mother and the fetus. - **Infants and Neonates**: In preterm infants or newborns with **respiratory distress syndrome (RDS)**, oxygen must be administered carefully to avoid **oxygen toxicity**, which can lead to **retinopathy of prematurity (ROP)** or **lung damage**. Special attention to oxygen concentration and duration is critical.

Indication

**Oxygenium** is used to provide supplemental oxygen for patients with various conditions that cause inadequate oxygen levels in the blood. It is indicated for: - **Hypoxemia**: **Oxygenium** is primarily used to correct low blood oxygen levels (**hypoxemia**) in conditions such as **acute respiratory failure**, **pneumonia**, **COPD exacerbations**, and **pulmonary edema**. - **Post-Surgical Recovery**: Oxygen is commonly used in patients recovering from major surgeries to help them maintain normal oxygen saturation and facilitate healing. - **Heart Failure**: Oxygen is also indicated for patients with **acute or chronic heart failure**, where it helps improve oxygenation and reduce the strain on the heart. - **Emergency Medicine**: **Oxygenium** is crucial in emergency situations such as **shock**, **cardiac arrest**, or **trauma**, where rapid oxygen delivery can stabilize the patient's condition. - **High Altitude Conditions**: **Oxygenium** is used to treat symptoms of **altitude sickness** in individuals who have difficulty acclimating to high altitudes due to reduced oxygen availability.

Contra indication

There are a few circumstances where the use of **Oxygenium** may be contraindicated or should be carefully monitored: - **Hyperoxia**: Excessive oxygen administration, especially over prolonged periods, can lead to **oxygen toxicity**, particularly in patients with **pre-existing lung disease**, **severe COPD**, or **brain injuries**. Oxygen toxicity can cause damage to the lungs and the central nervous system. - **Preterm Neonates**: Excessive oxygen in premature infants can lead to **retinopathy of prematurity (ROP)** or lung injury. Oxygen therapy for neonates must be very carefully controlled and monitored to avoid complications. - **Acute Myocardial Infarction (AMI)**: There is increasing evidence suggesting that administering oxygen unnecessarily during a **non-ST-elevation myocardial infarction (NSTEMI)** or in **uncomplicated AMI** could lead to worsened outcomes. Oxygen should be used with caution in these cases, as it may increase **coronary vasoconstriction**. - **Fire or Explosive Hazards**: Because **Oxygenium** is a highly flammable gas, it should not be used in environments with an increased risk of fire or explosion, such as near open flames or flammable materials.

Side Effect

While **Oxygenium** is generally considered safe, prolonged or excessive use can lead to certain side effects, including: - **Common Side Effects**: - **Dryness** and **irritation** of the nose, throat, or mucous membranes when using nasal cannulas or oxygen masks. - **Nasal congestion** or **nosebleeds**, especially with prolonged use. - **Headache**, which can occur due to oxygen levels being too high or too low. - **Fatigue** or **lightheadedness**, typically when oxygen levels fluctuate or are improperly administered. - **Severe Side Effects**: - **Oxygen Toxicity**: This occurs when oxygen is administered at concentrations that are too high for too long, and it can cause serious side effects, such as: - **Seizures** - **Visual disturbances** (blurry or tunnel vision) - **Tinnitus** (ringing in the ears) - **Chest pain or difficulty breathing** - **Barotrauma**: This is a condition caused by pressure from oxygen delivery systems, particularly under high-flow or hyperbaric conditions. It can result in **lung injury** or **middle ear problems**. - **Retinopathy of Prematurity (ROP)** in preterm infants, which can lead to vision impairment or blindness due to high oxygen levels administered in the neonatal period.

Pregnancy Category ID

0

Mode of Action

**Oxygenium** works by increasing the amount of **oxygen available** in the bloodstream, which is then transported to the tissues and organs. Oxygen is essential for **cellular respiration**, the process by which cells produce energy. When oxygen levels are insufficient, the body’s organs, particularly the **heart**, **brain**, and **muscles**, may not function effectively. The mechanism of action includes: - **Hemoglobin Binding**: Oxygen binds to **hemoglobin** in the red blood cells, forming **oxyhemoglobin**, which is then transported to tissues. - **Enhanced Cellular Respiration**: With adequate oxygen, cells can perform **aerobic respiration**, producing energy in the form of **ATP** that powers cellular activities. - **Restoration of Organ Function**: By ensuring adequate oxygenation, oxygen therapy helps maintain the function of vital organs, especially in patients with conditions such as **hypoxia**, **heart failure**, and **respiratory distress**.

Interaction

**Oxygenium** does not have significant drug-drug interactions. However, there are certain considerations: - **Medications for Respiratory Conditions**: Some medications like **bronchodilators**, **corticosteroids**, or **diuretics** (commonly used for conditions like asthma, COPD, and heart failure) may need to be adjusted in response to oxygen therapy. Oxygen may enhance the effects of certain treatments, but its levels should be monitored to avoid **oxygen toxicity** or exacerbating side effects. - **Volatile Anesthetics**: Oxygen should not be combined with certain **volatile anesthetics** (such as **halothane** or **isoflurane**) unless used under controlled medical supervision. The presence of oxygen can increase the risk of fire when using these anesthetics in surgical settings. - **Inhaled Nitric Oxide**: The combination of oxygen with **inhaled nitric oxide** (used to treat respiratory failure and pulmonary hypertension) requires careful monitoring. These substances can affect pulmonary circulation and oxygenation, and their use in combination should be closely managed by healthcare providers.

Pregnancy Category Note

Information not available

Adult Dose

The exact dose of **Oxygenium** depends on the patient's condition, oxygen saturation levels, and clinical response. Typically, the following methods are used to administer oxygen: - **Nasal Cannula**: For mild hypoxia, oxygen is delivered via a nasal cannula at a flow rate of **1-6 LPM**. The oxygen concentration ranges from **24% to 40%**, depending on the flow rate. - **Face Mask**: For moderate hypoxia, a **simple face mask** is used to deliver **5-10 LPM**, providing a higher oxygen concentration of **40% to 60%**. - **Non-Rebreather Mask**: For severe hypoxia or respiratory distress, a **non-rebreather mask** is used at **10-15 LPM**, delivering the highest oxygen concentration (around **60% to 90%**). - **Mechanical Ventilation**: For critically ill patients requiring intubation, **ventilators** are used, and oxygen is delivered at specific concentrations tailored to the patient’s needs. The healthcare provider will determine the appropriate delivery system and oxygen concentration based on clinical judgment.

Child Dose

The dosage of **Oxygenium** in pediatric patients depends on the child's age, weight, and medical condition. Oxygen should always be administered under medical supervision: - **Mild Hypoxia**: For neonates or children, **low-flow nasal cannulas** are typically used, starting at **1-2 LPM**. - **Moderate to Severe Hypoxia**: Higher oxygen concentrations may be delivered using a **face mask** or **non-rebreather mask**, with flow rates adjusted based on the child's oxygen saturation levels. - **Neonatal Care**: Oxygen therapy for premature infants or newborns with **respiratory distress syndrome (RDS)** should be carefully titrated to avoid **oxygen toxicity** or complications such as **ROP**. Close monitoring and professional healthcare management are crucial for adjusting oxygen doses appropriately for pediatric patients. ---

Renal Dose

There are no specific renal dose adjustments for **Oxygenium**, as it is not metabolized by the kidneys. However, **patients with renal impairment** should still be closely monitored, especially if they have co-existing conditions such as **cardiac failure** or **COPD**, which may require careful oxygen regulation to avoid complications.

Administration

Information not available