SISACURE 5mg/2.5ml Price

Overview

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This medicine contains an important and useful components, as it consists of
Cisatracurium besylateis available in the market in concentration

Name

Eszopiclone

Precaution

Before using **Eszopiclone**, it is essential for patients to consult their healthcare provider, particularly in the following cases: - **History of Sleep Disorders**: Eszopiclone is used to treat insomnia, but patients with a history of **sleep disorders** should use the medication with caution and under close supervision, as it may not be suitable for individuals with certain types of chronic sleep issues. - **Renal and Hepatic Impairment**: Patients with **liver disease** or **renal impairment** may need dose adjustments. Eszopiclone is primarily metabolized in the liver, so patients with **hepatic dysfunction** may experience increased drug levels. Renal function should also be monitored in patients with kidney problems. - **Pregnancy and Breastfeeding**: Eszopiclone is classified as **Category C** for pregnancy, meaning it may not be safe for use during pregnancy, especially in the **first trimester**, unless absolutely necessary. The medication can pass into breast milk, so caution should be used for breastfeeding mothers. - **Elderly Patients**: Older adults may be more susceptible to the **sedative effects** of Eszopiclone, leading to an increased risk of **drowsiness**, **falls**, and **cognitive impairment**. Dosage adjustments may be necessary to minimize these risks. - **Mental Health Conditions**: Patients with a history of **depression**, **mental health disorders**, or **suicidal thoughts** should use Eszopiclone with caution, as it may exacerbate these conditions. - **Alcohol and Drug Use**: Combining **Eszopiclone** with alcohol or other sedatives (e.g., **benzodiazepines**, **barbiturates**) can cause severe **sedation**, **respiratory depression**, and **cognitive impairment**. Patients should avoid alcohol while taking this medication.

Indication

**Eszopiclone** is a **sedative-hypnotic** medication primarily used to treat: - **Insomnia**: Eszopiclone is most commonly prescribed for the treatment of **short-term** and **long-term insomnia**. It helps patients with **sleep initiation** and **sleep maintenance** difficulties. - **Sleep Onset and Maintenance**: It is particularly effective for individuals who struggle to fall asleep or stay asleep during the night. Eszopiclone can improve both **sleep onset** and **sleep duration** in patients suffering from insomnia. - **Sleep Disturbances Due to Anxiety**: In some cases, Eszopiclone may be prescribed for people experiencing sleep difficulties related to anxiety or stress. However, its use should be monitored by a healthcare provider, especially when anxiety is severe. - **Pre-operative Sedation**: Although off-label, **Eszopiclone** may be used in certain medical settings as a **pre-operative sedative** to help calm patients prior to surgical procedures.

Contra indication

**Eszopiclone** should not be used in the following conditions: - **Hypersensitivity**: Individuals with a known **allergy** to **Eszopiclone** or any of its ingredients should avoid using this medication. Allergic reactions may include **rash**, **swelling**, or **difficulty breathing**, which require immediate medical attention. - **Severe Hepatic Impairment**: Eszopiclone is metabolized by the liver, so patients with **severe liver disease** or **hepatic impairment** should not use this medication, as it may cause an accumulation of the drug in the body, leading to **toxicity** and **sedation**. - **Sleep Apnea**: People with **severe sleep apnea** should avoid **Eszopiclone**, as sedatives may exacerbate respiratory problems during sleep. - **Severe Respiratory Insufficiency**: Due to the respiratory depressant effects of sedatives, patients with **severe respiratory conditions** (e.g., **chronic obstructive pulmonary disease (COPD)**) or **severe asthma** should not take **Eszopiclone**. - **Pregnancy**: As a **Category C** drug, **Eszopiclone** should be avoided during pregnancy, particularly in the **first trimester**, unless prescribed by a healthcare provider after careful consideration of potential risks.

Side Effect

Common side effects of **Eszopiclone** include: - **Drowsiness** and **sedation**: This is the intended effect of **Eszopiclone**, but it may cause **excessive drowsiness** the following day, impairing **alertness** and **coordination**. - **Headache**: Some patients may experience **headaches**, particularly after waking up from sleep. - **Dizziness**: **Dizziness** or a feeling of **lightheadedness** can occur, particularly when standing up quickly. - **Dry Mouth**: **Dry mouth** is a common side effect, and some people may also experience a **bitter taste**. - **Memory and Cognitive Issues**: Rarely, **Eszopiclone** may cause **amnesia** or **memory lapses**, particularly if taken in higher doses or in combination with other sedatives. - **Unusual Behaviors**: There have been reports of patients engaging in **sleepwalking**, **eating**, or even **driving** while not fully awake. These events can be dangerous and should be immediately reported to a healthcare provider. - **Allergic Reactions**: Severe allergic reactions, such as **rash**, **swelling of the face**, and **difficulty breathing**, though rare, require immediate medical attention. Serious side effects include **severe allergic reactions**, **worsening depression**, or **suicidal thoughts** in people with a history of **mental health issues**.

Pregnancy Category ID

3

Mode of Action

**Eszopiclone** is a **non-benzodiazepine sedative-hypnotic** that works by affecting the **GABA receptors** in the brain. It enhances the activity of **gamma-aminobutyric acid (GABA)**, an inhibitory neurotransmitter that promotes **sedation**, **relaxation**, and **sleep**. By binding to the **GABA-A receptors**, **Eszopiclone** increases **chloride ion influx**, which inhibits neuronal firing and **central nervous system activity**, leading to **sedation** and **sleep induction**. This action makes **Eszopiclone** effective for treating insomnia by promoting sleep onset and maintaining sleep without the same level of dependency or withdrawal symptoms seen with **benzodiazepines**.

Interaction

Eszopiclone may interact with a variety of medications, foods, and substances, including: - **CNS Depressants**: Combining **Eszopiclone** with other **central nervous system depressants** (e.g., **benzodiazepines**, **alcohol**, **barbiturates**, **antidepressants**) can enhance the sedative effects, leading to **increased drowsiness**, **respiratory depression**, and **cognitive impairment**. - **CYP3A4 Inhibitors**: **Eszopiclone** is metabolized by the **CYP3A4 enzyme**, and drugs that inhibit this enzyme (e.g., **ketoconazole**, **itraconazole**, **clarithromycin**) may increase **Eszopiclone** blood levels, leading to an increased risk of side effects. - **CYP3A4 Inducers**: Medications that induce **CYP3A4** (e.g., **rifampin**, **phenytoin**) may decrease the effectiveness of **Eszopiclone** by lowering its levels in the blood. - **Alcohol**: **Alcohol** should be avoided while taking **Eszopiclone**, as it can enhance the **sedative effects** and increase the risk of **over-sedation**, **respiratory depression**, and impaired **coordination**. - **Other Sedative Drugs**: Combining **Eszopiclone** with other sedatives, such as **antihistamines** or **muscle relaxants**, can have compounded **sedative effects**, leading to **excessive drowsiness** and **cognitive impairment**. - **Grapefruit**: **Grapefruit** can increase **Eszopiclone** levels in the body by inhibiting the **CYP3A4 enzyme**, leading to **increased drug effects** and potential side effects.

Pregnancy Category Note

Information not available

Adult Dose

The typical dose of **Eszopiclone** for adults is: - **Initial Dose**: **1 mg** taken **just before bedtime**. - **Dose Adjustment**: Depending on the patient’s response, the dose may be increased to **2 mg** or **3 mg**, but this is generally the maximum recommended dose. - **Elderly or Hepatic Impairment**: For elderly patients or those with liver impairment, the starting dose is typically **1 mg**, and dose adjustments are made carefully under medical supervision. Patients should use **Eszopiclone** for **short-term** management of insomnia, as long-term use may lead to **tolerance**, **dependence**, or **withdrawal symptoms**.

Child Dose

**Eszopiclone** is not approved for use in children under 18 years of age for the treatment of insomnia. The safety and efficacy in pediatric populations have not been established, and its use is not recommended in children.

Renal Dose

**Eszopiclone** does not require significant dose adjustments for patients with mild or moderate **renal impairment** (creatinine clearance above 30 mL/min). However, in patients with **severe renal impairment** (creatinine clearance below 30 mL/min), **Eszopiclone** should be used cautiously, and a lower dose may be recommended.

Administration

Information not available