SINEMET 250/25 Price

Overview

Welcome to Dwaey, specifically on SINEMET 250/25 page.
This medicine contains an important and useful components, as it consists of
Co-Careldopa (Levodopa, Carbidopa)is available in the market in concentration

Name

Carbidopa + Levodopa

Precaution

Heart disease, liver disease, dementia, psychosis, pregnancy, elderly, heart disease. Regular monitoring of renal and hepatic function is reccomended. Lactation: Drug inhibits lactation; use with caution

Indication

Parkinson's disease.

Contra indication

Lactation, narrow angle glaucoma, melanoma, psychosis, severely decompensated endocrine.

Side Effect

Edema,Agitation, anxiety, ataxia, bruxism, confusion, daytime somnolence decreased attention span, dyskinesia, dystonia, euphoria, insomnia, fainting, fatigue, increased trembling of hands, insouciance, malaise, memory loss, nightmares, nervousness, restlessness, trismus, vivid dreams,Alopecia, hot flushes, increased &/or dark perspiration, skin eruptions,Abdominal pain & discomfort, burning feeling in tongue, constipation, diarrhea, dysgeusia, dry mouth, dysphagia, hiccups, meteorism, sialorrhea, nausea, weight loss,Muscular spasms, muscular cramp,Hematuria, dark urine, incontinence, priapism, urine retention,Blurred vision, diplopia, dilated pupil, oculogyric problems. Potentially Fatal: Severe postural hypotension in elderly.

Pregnancy Category ID

3

Mode of Action

Levodopa is the metabolic precurosor of dopamine, it crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa increases the amount of levodopa that is transported into the CNS by inhibiting the decarboxylation of peripheral levodopa.

Interaction

Pyridoxine reverses effects of levodopa. Type-B MAOIs have synergistic effect. Effect reduced by phenothiazines, haloperidol, reserpine, pyridoxine, diazepam, oxazepam, chlordiazepoxide, phenobarbitone. Effects of levodopa enhanced by carbidopa, amantadine, anticholinergics, amphetamine. Effects of sympathomimetic agents enhanced. Potentially Fatal: Enhances hypotensive effects of bethanidine, bretylium, guanethidine. Hypertensive crises with furazolidone or MAO inhibitors.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration