SERENACE 10mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Haloperidolis available in the market in concentration

Name

Haloperidol

Precaution

Parkinsonism; epilepsy, allergy, angle-closure glaucoma, benign prostatic hyperplasia; severe cardiac or hepatic disease; extremes in temp (hot and cold weather); presence of acute infections or leucopenia; hyperthyroidism; pregnancy, elderly, children. Patients receiving anticoagulants. Discontinue upon signs of neurological toxicity in patients taking haloperidol and lithium. Lactation: Drug enters breast milk; not recommended

Indication

Schizophrenia, Delirium, Hiccups, Acute psychosis, Hyperactivity, Aggression, Agitation and confusion, Tic disorders, Tourette syndrome, Chorea, Nausea and vomiting, Dementia.

Contra indication

Severe toxic CNS depression; preexisting coma; Parkinson's disease; lactation.

Side Effect

Extrapyramidal symptoms Akathisia,Dystonia,Muscle stiffness,Neuroleptic malignant syndrome (NMS; infrequent but serious),Parkinsonism,Tardive dyskinesia Common Anticholinergic effects,Sedation,Weight gain,Erectile dysfunction,Oligomenorrhea or amenorrhea Less common Orthostatic hypotension (after IM injection), tachycardia Agitation, anxiety, cerebral edema, depression, dizziness, euphoria, headache, insomnia, poikilothermia, restlessness, weakness, confusion Anorexia, constipation, dyspepsia, ileus, decreased gag reflex Lens opacities (prolonged use) Uncommon ECG changes,Photosensitivity,Pruritus,Diarrhea,Blood dyscrasia,Ejaculatory disorder,Galactorrhea Rare Seizure,Cholestatic jaundice,Priapism Potentially Fatal: Neuroleptic malignant syndrome

Pregnancy Category ID

3

Mode of Action

Haloperidol blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It produces calmness and reduces aggressiveness with disappearance of hallucinations and delusions.

Interaction

Carbamazepine and rifampicin reduce plasma concentrations. Symptoms of CNS depression may be enhanced by CNS depressants e.g. alcohol, hypnotics, general anaesthetics, anxiolytics and opioids. May reduce antihypertensive action of guanethidine. May increase risk of arrhythmia when used with drugs that prolong QT interval or diuretics that can cause electrolyte imbalance. May increase plasma levels of haloperidol when used with clozapine or chlorpromazine. Potentially Fatal: Increases lithium blood levels and may predispose to neuroleptic malignant syndrome.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration