RETARPEN L.A. 1.2 MIU Price

Overview

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This medicine contains an important and useful components, as it consists of
Penicillin G benzathine (Benzathine benzylpenicillin)is available in the market in concentration

Name

Benzathine Penicillin

Precaution

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Lactation: Excreted into breast milk, caution advised

Indication

Anthrax, Group A Strep. infections, Neurosyphilis, Fusobacterium infections, Diphtheria, Erysipeloid, Uncomplicated pneumococcal pneumonia, Rat bite fever, Rheumatic fever, Syphilis, Streptococcal pharyngitis

Contra indication

Hypersensitivity to penicillins or cephalosporins. IM inj (ischaemic reactions may occur).

Side Effect

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Potentially Fatal: Anaphylaxis

Pregnancy Category ID

2

Mode of Action

Benzathine benzylpenicillin has the same antimicrobial action as benzylpenicillin which exerts its bactericidal action on growing and dividing bacteria by inhibiting bacterial cell wall synthesis. IM admin results in a prolonged effect, but because of its relatively low blood concentrations, its use should be restricted to microorganisms that are highly susceptible to it.

Interaction

Probenecid prolongs T1/2 of benzathine benzylpenicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration