RESYL 2% Price

Overview

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This medicine contains an important and useful components, as it consists of
Guaiphenesinis available in the market in concentration

Name

Mepyramine Maleate 2% Topical

Precaution

Mepyramine Maleate 2% Topical should be used cautiously in patients with a history of hypersensitivity to antihistamines or any of the components of the product. This topical medication contains an antihistamine, and overuse can lead to skin irritation or allergic reactions. Pregnant women should consult their healthcare provider before using mepyramine maleate, as there is limited data on the safety of its use during pregnancy. Similarly, breastfeeding mothers should seek advice, as the drug may pass into breast milk and could potentially affect a nursing infant. Patients with pre-existing conditions such as glaucoma, asthma, or urinary retention should use this medication under medical supervision, as antihistamines can exacerbate these conditions. It is also important to avoid the application of mepyramine maleate on broken or irritated skin, as this may increase the absorption of the medication and lead to increased risk of side effects. Monitoring for signs of excessive drowsiness or skin reactions is recommended, particularly when using the product over extended periods.

Indication

Mepyramine Maleate 2% Topical is primarily indicated for the relief of symptoms associated with allergic skin reactions, such as itching, hives, and rashes. It is used for conditions like insect bites, mild contact dermatitis, and other pruritic (itchy) skin conditions where antihistamine action is beneficial. Mepyramine maleate works by blocking histamine receptors (H1 receptors) on skin cells, which helps reduce itching and inflammation. While this medication is not typically used for more severe allergic conditions like anaphylaxis, it provides effective relief for localized skin reactions. There are no significant off-label uses for this medication, though it may occasionally be used for other mild skin irritation due to allergic reactions. As always, it is essential to use this medication as directed and consult a healthcare provider for more severe allergic conditions.

Contra indication

Mepyramine Maleate 2% Topical is contraindicated in patients with known hypersensitivity to mepyramine or any other antihistamine. It should also be avoided by individuals who have a history of severe allergic reactions to topical antihistamines. The medication is contraindicated for use on broken, inflamed, or irritated skin, as this could increase the risk of systemic absorption and lead to adverse effects. Children under the age of 2 years should not use this product, as they are particularly susceptible to the sedative effects of antihistamines, which could lead to respiratory depression or excessive sedation. Pregnant and breastfeeding women should consult with their healthcare provider before using mepyramine maleate to ensure the benefits outweigh potential risks. In patients with conditions such as glaucoma, prostatic hypertrophy, or asthma, this medication should only be used with caution under the supervision of a healthcare professional.

Side Effect

The most common side effects of Mepyramine Maleate 2% Topical include local skin reactions such as redness, itching, or a mild burning sensation at the site of application. These side effects are usually temporary and resolve once the medication is discontinued. In rare cases, patients may experience more severe allergic reactions, such as hives, swelling, or difficulty breathing, which would require immediate medical attention. Due to its antihistamine properties, Mepyramine may cause mild sedation, especially if used in larger amounts or over extended periods. This effect may be more pronounced if the medication is applied to large areas of skin or if it is combined with other sedative agents. Overuse of the medication may increase the risk of systemic side effects, such as dry mouth, blurred vision, or urinary retention, which are more common with oral antihistamines but may still occur with excessive topical use. If any signs of severe side effects, such as difficulty breathing or excessive sedation, occur, the patient should seek medical attention immediately.

Pregnancy Category ID

0

Mode of Action

Mepyramine Maleate 2% Topical exerts its therapeutic effect by blocking histamine receptors, specifically the H1 receptors on the surface of skin cells. Histamine is a chemical released during allergic reactions, leading to symptoms such as itching, redness, and inflammation. By inhibiting the action of histamine at the receptor sites, mepyramine reduces these allergic symptoms, providing relief from itching and swelling. Mepyramine maleate is a first-generation antihistamine, meaning it can cross the blood-brain barrier and may exert some sedative effects, although this is more common with systemic administration. When applied topically, the absorption is minimal, and the medication's primary action is confined to the skin, making it effective for localized treatment of allergic skin reactions without significant systemic effects.

Interaction

Mepyramine Maleate 2% Topical has minimal systemic absorption when used as directed, making it less likely to interact with other medications. However, caution is recommended when used in conjunction with other topical products containing antihistamines, as this could increase the risk of adverse reactions like skin irritation or excessive sedative effects. Patients using other medications that cause drowsiness, such as sedatives, tranquilizers, or alcohol, should be cautious, as mepyramine maleate can enhance the sedative effects. Systemic antihistamines, like those taken orally, may also have a combined effect when used with topical mepyramine maleate, increasing the risk of drowsiness or other CNS effects. While this medication does not typically have significant food interactions, patients should avoid using the topical product near mucous membranes, such as the eyes or mouth, to avoid irritation. It is always best to inform a healthcare provider about all medications being used, including over-the-counter treatments, to assess potential interactions.

Pregnancy Category Note

Information not available

Adult Dose

For adults, Mepyramine Maleate 2% Topical should be applied to the affected area 2-3 times per day, as needed for relief of allergic skin reactions. A thin layer of the cream or ointment should be gently massaged into the skin, taking care to avoid applying it to broken or irritated skin. It is important to use the medication as directed and to avoid excessive use, as overuse can increase the risk of side effects, including skin irritation or excessive sedation. The duration of treatment should be kept to a minimum, and if symptoms persist or worsen, a healthcare provider should be consulted for further evaluation. For localized skin conditions, this dosage is typically sufficient to manage symptoms without the risk of systemic absorption.

Child Dose

Mepyramine Maleate 2% Topical is not recommended for use in children under the age of 2 years due to the potential for systemic absorption and the increased risk of adverse reactions, including sedation and respiratory depression. For children older than 2 years, the product should be used sparingly, and the application should be limited to small areas of the skin. The typical adult dose of applying a thin layer to the affected area 2-3 times daily can be followed, but caution should be exercised. It is important to monitor the child closely for any signs of skin irritation, drowsiness, or other adverse effects. Prolonged use should be avoided, and the child should be reassessed by a healthcare provider if symptoms persist.

Renal Dose

Because Mepyramine Maleate 2% Topical is applied locally and has minimal systemic absorption, there are no specific renal dose adjustments required for patients with renal impairment. However, if the medication is used in excessive amounts or over large areas of broken skin, there is a risk of increased systemic absorption, which could affect renal function. In such cases, patients with renal impairment should use the product cautiously and be monitored for signs of side effects or toxicity, such as confusion or dry mouth. Generally, this medication is considered safe for patients with mild to moderate renal dysfunction when used appropriately.

Administration

Information not available