Active Substance: Strontium ranelate.
Overview
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This medicine contains an important and useful components, as it consists of
Strontium ranelateis available in the market in concentration
Strontium Renalate
Not recommended for use in patients with CrCl <30 ml/min. Patients at increased risk of venous thromboembolism. Pregnancy.
Postmenopausal osteoporosis
Patients w/ current or previous venous thromboembolic events including deep vein thrombosis and pulmonary embolism; temporary or permanent immobilisation due to post-surgical recovery or prolonged bed rest; current or history of ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease; uncontrolled HTN. Lactation.
Headache, GI disturbances, eczema, dermatitis; memory loss, consciousness disturbances, seizures, pyrexia, peripheral oedema, confusion, bronchial hyperreactivity. Angioedema, rash, urticaria, pruritus. Transient increases in creatine kinase activity (reversible). Potentially Fatal: Toxic epidermal necrolysis, Stevens-Johnson syndrome, and drug rash w/ eosinophilia and systemic symptoms.
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Strontium ranelate stimulates bone formation, osteoblast precursor replication and collagen synthesis. Decreasing osteoclast differentiation and resorbing activity, it reduces bone resorption resulting in a rebalance of bone turnover in favour of bone formation.
May reduce the absorption of oral tetracycline and quinolone antibiotics. Medicinal products containing Ca may reduce strontium ranelate bioavailability.
Information not available