PROLEUKIN 1mg Price

Overview

Welcome to Dwaey, specifically on PROLEUKIN 1mg page.
This medicine contains an important and useful components, as it consists of
Aldesleukinis available in the market in concentration

Name

Coal Tar + Precipitated Sulpher + Salicylic Acid

Precaution

When using a combination of Coal Tar, Precipitated Sulfur, and Salicylic Acid, patients should exercise caution under certain circumstances, particularly if they belong to special populations such as pregnant or breastfeeding women, or those with preexisting medical conditions. The combination of these active ingredients is commonly used topically for dermatological conditions, but it is crucial for pregnant women to consult with their healthcare provider, as some of the active ingredients, particularly salicylic acid, may carry risks during pregnancy, including potential teratogenic effects when used in large amounts or for prolonged periods. For breastfeeding women, these ingredients are considered safe in topical formulations, but caution is advised, especially if the cream or ointment comes into contact with areas like the breast. Patients with skin diseases, liver disease, or renal insufficiency should be carefully monitored, as systemic absorption can occur, leading to potential toxicity. Those with a history of hypersensitivity or allergic reactions to any component of the medication should avoid its use. Monitoring for skin irritation, erythema, and dryness should be done during treatment, especially in the first few days of use, to ensure the treatment's safety and efficacy. Overuse can lead to excessive skin peeling, irritation, or toxicity. There are no known addiction or dependency risks, as the formulation is not typically associated with misuse.

Indication

Coal Tar, Precipitated Sulfur, and Salicylic Acid are primarily indicated for the treatment of chronic skin conditions, notably psoriasis, seborrheic dermatitis, and other forms of eczema or dermatitis. The combination has been shown to effectively reduce skin scaling, inflammation, and itching, providing symptomatic relief for these conditions. Coal tar works as a keratolytic, helping to reduce scaling and slow down the rapid turnover of skin cells, which is a hallmark of psoriasis. Precipitated sulfur acts as an antimicrobial agent, reducing bacterial growth and preventing infection in compromised skin. Salicylic acid, a common keratolytic agent, aids in the removal of scales and thickened skin while also providing anti-inflammatory effects. Evidence-based guidelines, such as those from the American Academy of Dermatology, support the use of this combination therapy for mild to moderate cases of psoriasis and seborrheic dermatitis. While these ingredients are not typically recommended for severe cases, they are considered effective for maintenance therapy once the acute phase of the condition is under control. Off-label uses may include treatment of dandruff, other inflammatory scalp conditions, and localized keratoses. As this combination is topical, it is typically reserved for external use only.

Contra indication

This medication should be avoided by individuals with known hypersensitivity to any of its components, including coal tar, sulfur, or salicylic acid, as it may result in severe allergic reactions such as rashes, swelling, or anaphylaxis. In addition, it is contraindicated in individuals with open or broken skin, as the active ingredients may cause irritation or worsen existing damage. This medication should not be used in large quantities or on sensitive areas like the face, mucous membranes, or genital regions without a healthcare provider's guidance, due to potential for excessive irritation or systemic absorption. For patients with severe renal or hepatic impairment, caution is advised due to the potential for altered drug metabolism and the increased risk of adverse effects. It is also contraindicated in patients under the age of 2, as the safety and efficacy in younger children have not been established. Elderly patients, who may have more sensitive skin or underlying chronic conditions, should use this medication under close medical supervision. In addition, this combination should be avoided in pregnancy unless deemed necessary by a healthcare provider, especially during the first trimester.

Side Effect

The side effects of Coal Tar, Precipitated Sulfur, and Salicylic Acid are generally mild but can vary depending on the individual’s skin type and the area of application. The most common side effects include mild skin irritation, redness, burning, or stinging at the site of application. These reactions are typically transient and improve as the skin acclimates to the medication. In some cases, excessive dryness or peeling may occur, particularly if the treatment is used too frequently or in large amounts. Less common but more severe side effects include allergic reactions such as swelling, hives, or difficulty breathing, which require immediate medical attention. Prolonged use, especially over large areas, may lead to systemic absorption, increasing the risk of salicylate toxicity, which could manifest as tinnitus, dizziness, nausea, or confusion. To minimize these risks, patients should avoid applying the medication to broken or irritated skin, and follow the prescribed usage guidelines closely. If irritation persists or becomes severe, the patient should discontinue use and consult a healthcare provider for further evaluation.

Pregnancy Category ID

3

Mode of Action

Coal Tar, Precipitated Sulfur, and Salicylic Acid work synergistically to treat skin conditions by targeting multiple aspects of the skin’s structure and function. Coal tar acts as a topical anti-inflammatory and antiproliferative agent, helping to slow the excessive cell turnover seen in conditions like psoriasis. It also helps to reduce itching and redness by stabilizing the skin's cell growth and suppressing inflammatory cytokines. Precipitated sulfur has antimicrobial and keratolytic properties, helping to prevent infection and soften the skin, which can be particularly useful in treating conditions that involve scaling or thickened skin. It also acts as a mild antifungal, further supporting the skin’s barrier function. Salicylic acid serves as a powerful keratolytic agent, promoting the shedding of dead skin cells and reducing the buildup of scales, which is particularly important in conditions like psoriasis and seborrheic dermatitis. Salicylic acid also exerts mild anti-inflammatory effects, reducing skin redness and irritation. These combined effects make the medication effective for treating scaling disorders and promoting healthier skin turnover.

Interaction

Drug-drug interactions with Coal Tar, Precipitated Sulfur, and Salicylic Acid are generally minimal due to the topical nature of the treatment. However, caution should be exercised if the patient is using other keratolytic or exfoliating agents, such as tretinoin or other salicylic acid preparations, as this could lead to excessive skin irritation or peeling. Additionally, combining this medication with other topical treatments, such as corticosteroids, may cause increased skin thinning, and this should be avoided unless directed by a healthcare provider. Systemic interactions may occur if the medication is applied over large areas of the body, particularly with the salicylic acid component, which can be absorbed into the bloodstream and may interfere with the action of blood thinners like warfarin. The combination may also reduce the effectiveness of certain antibiotics or increase the risk of adverse effects when used alongside some immunosuppressive drugs, such as methotrexate. Alcohol use does not directly affect the efficacy of the medication, but it can exacerbate skin irritation or dryness. Patients should avoid alcohol consumption if they experience significant skin dryness or irritation during treatment. Lifestyle factors such as sun exposure should be limited, as the active ingredients may make the skin more sensitive to UV radiation, increasing the risk of burns or irritation.

Pregnancy Category Note

Information not available

Adult Dose

The typical adult dose of Coal Tar, Precipitated Sulfur, and Salicylic Acid depends on the formulation (e.g., ointment, cream, shampoo). For topical applications, a thin layer of the medication should be applied to the affected area once or twice daily, depending on the severity of the condition. It is important to avoid excessive use, as over-application can lead to skin irritation or systemic absorption of salicylic acid. For patients with more sensitive skin, or those new to the treatment, it may be appropriate to start with a less frequent application (e.g., every other day) and gradually increase usage as tolerated. In some cases, patients with severe psoriasis may require higher doses or more frequent application, but this should only be done under medical supervision. The maximum daily dose should not exceed the amount prescribed by the healthcare provider, typically around 1–2 ounces per day. For scalp conditions, the product may be applied to damp hair, left for several minutes, and then rinsed.

Child Dose

In pediatric patients, Coal Tar, Precipitated Sulfur, and Salicylic Acid should only be used under the guidance of a healthcare provider. The safety and efficacy in children under 2 years of age have not been established, so the use of this combination in younger children is generally contraindicated. For children aged 2 to 12 years, the dose is typically lower than for adults, with application limited to a thin layer once a day or every other day, depending on the severity of the skin condition. Pediatric patients may have more sensitive skin, so close monitoring for irritation, redness, or signs of systemic toxicity is essential. Care should be taken not to apply the medication to broken skin or large areas to minimize the risk of excessive absorption of salicylic acid. For children over 12 years of age, the adult dose may be appropriate, but again, regular monitoring is essential to avoid side effects or complications.

Renal Dose

In patients with renal impairment, particular caution should be exercised when using Coal Tar, Precipitated Sulfur, and Salicylic Acid, especially over large areas or for extended periods. Renal dysfunction may impair the elimination of salicylic acid, leading to an increased risk of systemic toxicity, which can manifest as tinnitus, confusion, or gastrointestinal disturbances. In these patients, the dosage should be reduced, and the area of application should be minimized to avoid systemic absorption. For patients with mild renal impairment (creatinine clearance >60 mL/min), standard dosing can generally be used, though closer monitoring of renal function is recommended. For moderate to severe renal impairment (creatinine clearance <60 mL/min), the frequency of application should be reduced, and the patient should be monitored closely for signs of salicylate toxicity. Regular renal function tests should be conducted to assess any impact on the kidneys.

Administration

Information not available