PLIAGLIS Price

Overview

Welcome to Dwaey, specifically on PLIAGLIS page.
This medicine contains an important and useful components, as it consists of
Lidocaine Ð Tetracaineis available in the market in concentration

Name

Sodium Hyaluronate

Precaution

Before using **Sodium Hyaluronate**, patients should consult their healthcare provider to ensure it is safe for them, particularly in the following circumstances: - **Allergic reactions**: Patients who have a known **sensitivity** or **allergy** to hyaluronic acid, its derivatives, or any components in the product should avoid using **Sodium Hyaluronate**. - **Intra-articular use**: When used for joint injections (such as for osteoarthritis), **Sodium Hyaluronate** should be administered by a healthcare professional. Improper injection or administration can cause **joint infections**, **swelling**, or **pain**. - **Skin applications**: If used in topical formulations, **Sodium Hyaluronate** should be avoided on areas of skin that are **broken**, **infected**, or **irritated**. - **Pregnancy and breastfeeding**: While **Sodium Hyaluronate** is generally considered safe in pregnancy, especially for topical use, pregnant or breastfeeding women should consult their healthcare provider before using the product. - **Chronic skin conditions**: If a patient has a **chronic skin condition** like **eczema** or **psoriasis**, it is advisable to speak to a healthcare provider before using Sodium Hyaluronate to avoid worsening symptoms.

Indication

**Sodium Hyaluronate** has various therapeutic uses, including: - **Osteoarthritis management**: **Sodium Hyaluronate** is commonly used as an intra-articular injection to treat **osteoarthritis**, particularly in the knee joint. It helps to **lubricate the joint**, reducing pain and improving joint mobility by restoring the **viscosity** and **elasticity** of the synovial fluid. - **Eye care**: It is used in ophthalmology as a **lubricating** agent for dry eyes, to **treat eye irritation**, and as a **viscoelastic agent** in cataract surgery, improving surgical outcomes by providing protection to the corneal endothelium. - **Wound healing**: **Sodium Hyaluronate** is used in certain **wound healing** applications, including as part of **dressing materials** to promote faster tissue repair, particularly in ulcers or burns, due to its moisturizing and **regenerative properties**. - **Dermatology**: In topical formulations, it is often used in skin care for its **hydrating** properties to treat dry skin, **wrinkles**, and to enhance skin elasticity. It is a common ingredient in **cosmetic formulations** such as creams, serums, and facial masks.

Contra indication

**Sodium Hyaluronate** should not be used in the following situations: - **Hypersensitivity**: Individuals with known allergies to **Sodium Hyaluronate**, **hyaluronic acid**, or any of the excipients used in the formulation should not use this product. - **Active joint infections**: For intra-articular injections, **Sodium Hyaluronate** should not be used in patients with active **joint infections** or **severe skin infections** in the area where the injection is to be administered. - **Severe knee instability**: In patients with severe **knee instability** or conditions where joint movement is severely restricted, **Sodium Hyaluronate** injections may not be appropriate without further medical evaluation. - **Open wounds**: For topical use, **Sodium Hyaluronate** should be avoided on **open wounds** or areas with **severe skin conditions** that may require a different treatment approach.

Side Effect

While generally well-tolerated, **Sodium Hyaluronate** can cause the following side effects: - **Intra-articular injections**: - **Pain** at the injection site is the most common side effect. - **Swelling**, **redness**, or **warmth** at the injection site may occur. - Rarely, **infection**, **joint effusion** (fluid buildup), or **bleeding** may occur. - **Topical use**: - **Skin irritation** or mild **redness** may occur in some individuals, especially those with sensitive skin. - Prolonged use of topical formulations may rarely lead to **contact dermatitis** in highly sensitive individuals. - There is also a slight possibility of **allergic reactions**, including **itching**, **rash**, or **swelling**. - **Eye drops**: - Mild **eye irritation** or **stinging** is possible when **Sodium Hyaluronate** is used in eye drops. - Rarely, some individuals may experience **blurry vision** or **eye discomfort**, but these side effects are typically mild and transient.

Pregnancy Category ID

0

Mode of Action

**Sodium Hyaluronate** works through its **lubricating** and **hydrating properties**: - **Lubrication and joint protection**: In intra-articular applications, **Sodium Hyaluronate** acts as a **viscoelastic agent**, mimicking the properties of the natural **synovial fluid**. It helps **reduce friction** between the bones in the joint, easing movement and decreasing pain, especially in conditions like **osteoarthritis**. - **Wound healing and tissue repair**: **Sodium Hyaluronate** promotes wound healing by providing a **moist environment**, which enhances tissue regeneration and reduces scar formation. It also helps recruit **fibroblasts** and **growth factors**, which are essential for healing. - **Skin hydration**: When applied topically, **Sodium Hyaluronate** binds to water molecules and forms a **moisture-retaining barrier** on the skin, which helps hydrate and plump the skin. It supports the skin’s natural **barrier function**, reducing water loss and preventing dryness. - **Regeneration and anti-aging**: In skin care products, **Sodium Hyaluronate** helps promote **cell turnover**, reducing the appearance of **fine lines** and **wrinkles**, improving skin elasticity, and creating a smoother appearance.

Interaction

There are generally no major interactions with **Sodium Hyaluronate**, but patients should consider the following: - **Corticosteroids**: When used for joint injections, caution should be exercised when combining **Sodium Hyaluronate** with **corticosteroid injections**. Some studies suggest that concurrent use may increase the risk of **joint infection** or reduce the therapeutic efficacy of **Sodium Hyaluronate**. - **Other hyaluronic acid-based products**: Using multiple **hyaluronic acid-based products** (such as combining **topical products** and **injectable formulations**) may increase the likelihood of experiencing **skin irritation** or an **allergic reaction**. - **Anticoagulants**: Injections of **Sodium Hyaluronate** should be used cautiously in patients on **anticoagulant** therapy, as the risk of **bleeding** at the injection site may be increased. - **Topical medications**: When applied topically, **Sodium Hyaluronate** may interact with other moisturizing or skin treatments, so it is important to check for compatibility if combined with other products.

Pregnancy Category Note

Information not available

Adult Dose

The dosage of **Sodium Hyaluronate** depends on the specific therapeutic use: - **Intra-articular injections** for osteoarthritis are typically administered **once a week for 3 to 5 weeks**, with the exact dosage and number of injections varying depending on the product used. The dose typically ranges from **2.5 to 6 mL** per injection. - **Topical use**: For moisturizing or anti-aging purposes, a small amount (usually **1-2 drops** or a pea-sized amount) of **Sodium Hyaluronate gel/serum** is applied to clean, dry skin once or twice daily. - **Eye care**: For dry eyes, **Sodium Hyaluronate** eye drops are generally used **1-2 drops** in each eye, **3 to 4 times daily**, or as directed by a healthcare professional.

Child Dose

For **children**, the use of **Sodium Hyaluronate** should be guided by a healthcare provider, as there are fewer studies and indications for its use in pediatric patients. - **Intra-articular injections**: In pediatric patients, **Sodium Hyaluronate** should only be administered under the guidance of a pediatric rheumatologist or orthopedic specialist. The dosage and frequency may vary based on the child’s age, weight, and medical condition. - **Topical use**: For **children**, the topical use of **Sodium Hyaluronate** should be limited to products that are specifically formulated for young skin. The typical dosage is similar to that used in adults, but application should be limited to smaller areas of skin, particularly in children under 3 years old. As always, it is essential for patients (or their caregivers) to consult a healthcare provider before using **Sodium Hyaluronate**, particularly in children or individuals with other medical conditions, to ensure safe and effective use.

Renal Dose

**Sodium Hyaluronate** is primarily used topically or via injection and is minimally absorbed systemically, so there are generally no specific dose adjustments required for **renal impairment**. However, in patients with **severe kidney disease** who require intra-articular injections, careful monitoring may be needed to ensure safety, particularly if the patient is also taking medications that affect kidney function.

Administration

Information not available