PHILAZOLE 2% price in UAE

Overview

Welcome to Dwaey, specifically on PHILAZOLE 2% Cream page.
This medicine contains an important and useful components, as it consists of Ketoconazole.
PHILAZOLE 2% is available in the market in concentration 20mg/g and in the form of Cream.

PHILADELPHIA PHARMACEUTICALS is the producer of PHILAZOLE 2% and it is imported from JORDAN, The most popular alternatives of PHILAZOLE 2% are listed downward .

Mode Of Action

Ketoconazole interferes w/ biosynthesis of triglycerides and phopholipids by blocking fungal CYP450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.

Indication

Candidiasis
Fungal infections
Pityriasis versicolor
Seborrhoeic dermatitis

Precaution

Hepatic impairment; monitor liver function regularly. Pregnancy, lactation. Predisposition to adrenocortical insufficiency. Discontinue treatment if there is persistent or worsening of liver enzyme elevation.

Side Effects

1-10% Nausea and vomiting (3-10%)
Pruritus (2%)
Abdominal pain (1%) <1% Alopecia
Headache
Dizziness
Hyperlipidemia
Somnolence
Fever
Chills
Bulging fontanelles
Depression
Gynecomastia
Diarrhea
Impotence
Thrombocytopenia
Leukopenia
Hemolytic anemia
Erythema multiforme
Orthostatic hypotension
Jaundice
Dyspepsia
Dysgeusia
Hepatotoxicity
Decreased platelet count
Xeroderma
Photophobia Potentially Fatal: Hepatotoxicity.

Contra indication

Hypersensitivity; preexisting liver disease, porphyria. Concurrent use with cisapride, terfenadine or astemizole.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Interaction

Reduced absorption w/ antimuscarinics, antacids, H2-blockers, PPIs, sucralfate. Reduced plasma concentrations w/ rifampicin, isoniazid, efavirenz, nevirapine, phenytoin. May also reduce concentrations of isoniazid and rifampicin. May reduce efficacy of oral contraceptives. May increase serum levels of CYP3A4 substrates e.g. digoxin, oral anticoagulants, sildenafil, tacrolimus. Potentially Fatal: May potentiate and prolong sedative and hypnotic effects of midazolam and triazolam. Increased plasma levels and prolonged QT intervals of astemizole, cisapride, dofetilide, pimozide, quinidine and terfenadine which may lead to torsade de pointes. Increased risk of myopathy w/ HMG-CoA reductase inhibitors (e.g. lovastatin, simvastatin). Markedly increased plasma levels of nisoldipine. Increased risk of hyperkalaemia and hypotension w/ eplerenone. Increased risk of vasospasm potentially leading to cerebral ischaemia w/ ergot alkaloids (e.g. ergotamine, dihydroergotamine).