PEMETREXED KARMA 500mg price in UAE

Overview

Welcome to Dwaey, specifically on PEMETREXED KARMA 500mg Powder for Concentrate for Solution for Infusion page.
This medicine contains an important and useful components, as it consists of Pemetrexed.
PEMETREXED KARMA 500mg is available in the market in concentration 500 mg/50 ml and in the form of Powder for Concentrate for Solution for Infusion.

PHARMA RESOURCES GMBH is the producer of PEMETREXED KARMA 500mg and it is imported from GERMANY, The most popular alternatives of PEMETREXED KARMA 500mg are listed downward .

Mode Of Action

Pemetrexed is a thymidylate synthase inhibitor. It works by inhibiting thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase and aminoimidazole carboxamide ribonucleotide formyltransferase, the enzymes involved in folate metabolism and DNA synthesis, thus inhibiting purine and thymidine nucleotide and protein synthesis.

Indication

Non-small cell lung cancer
Malignant pleural mesothelioma

Precaution

Monitor CBC, platelet counts, and CrCl for nadir and recovery before each cycle. Periodic hepatic monitoring Premedication with folate and vitamin B12 are recommended as prophylaxis against haematological and GI toxicity during treatment. Pre-treatment with a corticosteroid also reduces the incidence and severity of skin reactions. Caution when used in renal or hepatic impairment. Not recommended for use in pregnancy. Lactation: not safe

Side Effects

>10% Nausea (84%)
Fatigue (80%)
Pulmonary dyspnea (66%)
Neutropenia (58%)
Vomiting (58%)
Leukopenia (55%)
Constipation (44%)
Chest pain (40%)
Anorexia (35%)
Anemia (33%)
Pharyngitis (28%)
Stomatitis (28%)
Thrombocytopenia (27%)
Diarrhea without colostomy (26%)
Rash/desquamation (22%)
Fever (17%)
Neuropathy/sensory (17%)
Creatinine elevation (16%)
Mood alteration/depression (14%)
Infection without neutropenia (11%) 1-10% Dehydration
thrombosis/embolism (7%)
Dysphagia/esophagitis/odynophagia (6%)
Infection with Grade 3 or Grade 4 neutropenia (6%)
Neutropenia-other (3%)
Allergic reaction/hypersensitivity (2%)
Renal failure (2%)
Febrile neutropenia (1%) <1% Esophagitis
Arrhythmia
Motor neuropathy
Febrile neutropenia
Erythema multiforme Potentially Fatal: Acute renal failure.

Contra indication

Hypersensitivity.

Pregnancy and lactation

Pregnancy category: D

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Interaction

High doses of NSAIDs and aspirin may reduce the elimination of pemetrexed; avoid usage 2 days (5 days for longer-acting NSAIDs) before, during and 2 days after treatment with pemetrexed in patients with impaired renal function. Additive GI side effects when used with SSRIs, acetylcholinesterase inhibitors, aripiprazole or ziprasidone. Additive sedation when used with psychotropics. Concurrent use with nephrotoxic drugs (e.g. aminoglycosides, loop diuretics, platinum compounds and ciclosporin) may decrease pemetrexed clearance, thus increasing the risk of toxicity. Clearance may be reduced when used with drugs that are cleared by tubular secretion e.g. probenecid and penicillin.

UAD 3059

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