PEMETREXED KARMA 500mg Price

Overview

Welcome to Dwaey, specifically on PEMETREXED KARMA 500mg page.
This medicine contains an important and useful components, as it consists of
Pemetrexedis available in the market in concentration

Name

Pemetrexed

Precaution

Monitor CBC, platelet counts, and CrCl for nadir and recovery before each cycle. Periodic hepatic monitoring Premedication with folate and vitamin B12 are recommended as prophylaxis against haematological and GI toxicity during treatment. Pre-treatment with a corticosteroid also reduces the incidence and severity of skin reactions. Caution when used in renal or hepatic impairment. Not recommended for use in pregnancy. Lactation: not safe

Indication

Non-small cell lung cancer, Malignant pleural mesothelioma

Contra indication

Hypersensitivity.

Side Effect

>10% Nausea (84%),Fatigue (80%),Pulmonary dyspnea (66%),Neutropenia (58%),Vomiting (58%),Leukopenia (55%),Constipation (44%),Chest pain (40%),Anorexia (35%),Anemia (33%),Pharyngitis (28%),Stomatitis (28%),Thrombocytopenia (27%),Diarrhea without colostomy (26%),Rash/desquamation (22%),Fever (17%),Neuropathy/sensory (17%),Creatinine elevation (16%),Mood alteration/depression (14%),Infection without neutropenia (11%) 1-10% Dehydration, thrombosis/embolism (7%),Dysphagia/esophagitis/odynophagia (6%),Infection with Grade 3 or Grade 4 neutropenia (6%),Neutropenia-other (3%),Allergic reaction/hypersensitivity (2%),Renal failure (2%),Febrile neutropenia (1%) <1% Esophagitis,Arrhythmia,Motor neuropathy,Febrile neutropenia,Erythema multiforme Potentially Fatal: Acute renal failure.

Pregnancy Category ID

4

Mode of Action

Pemetrexed is a thymidylate synthase inhibitor. It works by inhibiting thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase and aminoimidazole carboxamide ribonucleotide formyltransferase, the enzymes involved in folate metabolism and DNA synthesis, thus inhibiting purine and thymidine nucleotide and protein synthesis.

Interaction

High doses of NSAIDs and aspirin may reduce the elimination of pemetrexed; avoid usage 2 days (5 days for longer-acting NSAIDs) before, during and 2 days after treatment with pemetrexed in patients with impaired renal function. Additive GI side effects when used with SSRIs, acetylcholinesterase inhibitors, aripiprazole or ziprasidone. Additive sedation when used with psychotropics. Concurrent use with nephrotoxic drugs (e.g. aminoglycosides, loop diuretics, platinum compounds and ciclosporin) may decrease pemetrexed clearance, thus increasing the risk of toxicity. Clearance may be reduced when used with drugs that are cleared by tubular secretion e.g. probenecid and penicillin.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration