ALKERAN 2mg Price

Overview

Welcome to Dwaey, specifically on ALKERAN 2mg page.
This medicine contains an important and useful components, as it consists of
Melphalanis available in the market in concentration

Name

Melphalan

Precaution

Renal impairment. Lactation. Prior bone marrow suppression, prior chemotherapy or irradiation. May mask signs of infection e.g. fever and increased WBC. Elderly. Lactation: not known if excreted in breast milk

Indication

Breast cancer, Ovarian cancer, Multiple myeloma, Neuroblastoma, Soft tissue sarcoma, Malignant melanoma, Retinoblastoma, Polycythaemia vera

Contra indication

Hypersensitivity. Severe bone marrow suppression. Pregnancy.

Side Effect

>10% Myelosuppression (30%) Frequency Not Defined Diarrhoea, stomatitis, vomiting; haemolytic anaemia, vasculitis, pulmonary fibrosis, hepatic disorders, suppression of ovarian function in premenopausal women, temporary or permanent sterility in male patients. Allergic reactions. Potentially Fatal: Bone marrow suppression. Secondary malignancy, cardiac arrest. Anaphylaxis.

Pregnancy Category ID

4

Mode of Action

Melphalan, a mechlorethamine derivative, is an alkylating antineoplastic agent. It forms carbonium ions, resulting in DNA and RNA synthesis inhibition. It cross-links DNA strands and acts on both resting and rapidly dividing tumour cells.

Interaction

Potentially Fatal: Fatal haemorrhagic enterocolitis with concurrent nalidixic acid in children. Potentiates risk of renal damage with ciclosporin.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration