Active Substance: Triptorelin.
Overview
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This medicine contains an important and useful components, as it consists of
Triptorelinis available in the market in concentration
Triptorelin Acetate
Patients with pituitary adenoma; weight-related amenorrhoea until weight corrected; polycystic ovary disease or endometriotic cysts; metabolic bone disease. Monitor closely as there may be initial worsening of signs and symptoms during first few wk of therapy. Contraceptive measures to be taken to protect against unwanted ovulation in females.
Uterine fibroids, Female infertility, Endometriosis, Prostate cancer
Hypersensitivity to triptorelin and other luteinising hormone-releasing hormone (LHRH) or LHRH agonists; as sole treatment in prostate cancer patients with spinal cord compression or evidence of spinal metastases; progressive brain tumours in children. Pregnancy; lactation.
>10% Hot flushes (82%),Skeletal pain (17%) 1-10% Impotence (10%),Headache (7%),Hypertension (5%),Injection site pain (5%),Generalized pain (3%),Vomiting (3%),Fatigue (3%),Insomnia (3%),UTI (3%),Diarrhea (2%),Pruitus (2%),UTI (2%),Spinal cord compression (rare) Potentially Fatal: Anaphylactic shock.
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Triptorelin is a synthetic analogue of natural gonadotropin-releasing hormone. Initial admin stimulates the release of pituitary gonadotrophins with a transient increase in testosterone levels in men and in oestradiol levels in women, leading to an initial worsening of symptoms during the first wk. Prolonged admin leads to a suppression of gonadotrophins and a decrease in plasma testosterone or oestradiol after approximately 20 days, which is maintained for as long as triptorelin is admin.
Decrease in LHRH receptors in pituitary with hyperprolactinaemic drugs antagonises effects of triptorelin.
Information not available