NIFEDI-DENK 20 Retard price in UAE

Overview

Welcome to Dwaey, specifically on NIFEDI-DENK 20 Retard Tablets/Prolonged Release page.
This medicine contains an important and useful components, as it consists of Nifedipine .
NIFEDI-DENK 20 Retard is available in the market in concentration 20 mg/Tablet and in the form of Tablets/Prolonged Release.

DENK PHARMA GmbH & Co. KG is the producer of NIFEDI-DENK 20 Retard and it is imported from GERMANY, The most popular alternatives of NIFEDI-DENK 20 Retard are listed downward .

Mode Of Action

Nifedipine prevents Ca ion from entering the slow channels of cardiac and smooth muscles during depolarisation, producing peripheral and coronary vasodilatation. It reduces afterload, peripheral resistance and BP; increases coronary blood flow and causes reflex tachycardia. It has little or no effect on cardiac conduction and rarely has negative inotropic activity.

Indication

Hypertension
Angina pectoris
Raynaud's syndrome
Stroke prevention

Precaution

Patients w/ hypotension, poor cardiac reserve, heart failure, severe aortic stenosis, DM, underlying severe GI narrowing (extended-release tab). Avoid abrupt withdrawal as it may casue rebound angina. Hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling Discontinue if ischaemic pain follows after admin. Monitoring Parameters Monitor BP, heart rate. Lactation: Drug is distributed into breast milk; manufacturer suggests discontinuing drug or refraining from nursing (however, American Academy of Pediatrics states that drug is safe for nursing)

Side Effects

>10% Peripheral edema (10-30%)
Dizziness (23-27%)
Flushing (23-27%)
Headache (10-23%)
Heartburn (11%)
Nausea (11%) 1-10% Muscle cramps (8%)
Mood change (7%)
Nervousness (7%)
Cough (6%)
Dyspnea (6%)
Palpitations (6%)
Wheezing (6%)
Hypotension
transient (5%)
Urticaria (2%)
Pruritus (2%)
Constipation (<2%)
Chest pain (<2%) Frequency Not Defined Gingival hyperplasia
Agranulocytosis
Erectile dysfunction

Contra indication

Acute MI, cardiogenic shock, acute unstable angina, treatment of anginal attack in chronic stable angina.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Interaction

Enhanced antihypertensive effects w/ other antihypertensives, aldesleukin, and antipsychotics. Concomitant use w/ fentanyl during surgery caused severe hypotension. May modify insulin and glucose responses. Attenuation of tachycardic effect when used w/ benazerpril. Prothrombin time may be increased w/ coumarin anticoagulants. Increased serum levels w/ CYP3A4 inhibitors (e.g. azole antifungals, cimetidine, erythromycin, HIV-protease inhibitors, nefazodone, fluoxetine, quinupristin/dalfopristin). Potentially Fatal: Decreased bioavailability and efficacy w/ strong CYP3A4 inducers (e.g. rifampicin, phenytoin, carbamazepine).