MELADININE Price

Overview

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This medicine contains an important and useful components, as it consists of
Methoxsalen (Ammoidin), Pentosalen (Ammidin)is available in the market in concentration

Name

Methoxsalen

Precaution

Patient exhibiting multiple basal cell carcinoma or history of basal cell carcinoma, previous arsenic therapy, previous x-ray or grenz ray therapy; cardiac diseases or those unable to tolerate prolonged standing or exposure to heat stress; GI diseases or chronic infection. Hepatic impairment. Pregnancy and lactation. Lactation: not known whether excreted in breast milk; use caution

Indication

Psoriasis, Vitiligo, Eczema, T-Cell Lymphoma

Contra indication

Hypersensitivity. Aphakia, existing or history of melanoma, invasive squamous cell carcinoma, photosensitivity diseases (e.g. porphyria, acute lupus erythematosus, xeroderma pigmentosum).

Side Effect

All Patients Mild-moderate erythema x 24-48 hrs 1-10% Nausea,Pruritis Frequency Not Defined Edema,Dizziness,Headache,Malaise,Depression,Hypopigmentation,Bullae formation,Rash,Herpes simplex,Uritcaria,GI disturbances,Leg cramps,Hypotension,Extension of psoriasis

Pregnancy Category ID

3

Mode of Action

Methoxsalen increases skin reactivity to long-wavelength UV rays. It bonds covalently to DNA inhibiting DNA synthesis and cell division, which can lead to cell injury. This effect is used in photochemotherapy or PUVA and high-intensity long-wavelength UVA irradiation].

Interaction

Additive effects with drugs known to cause photosensitisation e.g. anthralin, coal tar or derivatives, griseofulvin, phenothiazines, nalidixic acid, sulfonamides., tetracyclines and thiazide diuretics. May increase the levels/effects of aminophylline, fluvoxamine, mexiletine, mirtazapine, ropinirole, theophylline, trifluoperazine, dexmedetomidine and ifosfamide.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration