DARZALEX 400mg/20ml Price

Overview

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This medicine contains an important and useful components, as it consists of
Daratumumabis available in the market in concentration

Name

Amlodipine + Telmisartan

Precaution

May increase frequency and/or severity of angina during treatment initiation or dosage increments. Heart failure or hepatic impairment. Lactation: Discontinue drug or do not breast feed

Indication

Hypertension

Contra indication

Liver insufficiency. Pregnancy.

Side Effect

>10% Peripheral edema (1-11%) 1-10% Dizziness (3%),Orthostatic hypotension (6%),Syncope (2%),Back pain (2%)

Pregnancy Category ID

17

Mode of Action

Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina. Telmisartan is a nonpeptide AT1 angiotensin II receptor antagonist. It exerts antihypertensive activity by preventing angiotensin II from binding to AT1 receptors thus inhibiting the vasoconstricting and aldosterone-secreting effects of angiotensin II.

Interaction

Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina.

Pregnancy Category Note

Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)

Adult Dose

Child Dose

Renal Dose

Administration