MABTHERA 500mg/50ml Price

Overview

Welcome to Dwaey, specifically on MABTHERA 500mg/50ml Infusion/Concentrate for page.
This medicine contains an important and useful components, as it consists of Rituximab.
MABTHERA 500mg/50ml is available in the market in concentration 10mg/ml and in the form of Infusion/Concentrate for.

F. HOFFMANN-LA ROCHE LTD. is the producer of MABTHERA 500mg/50ml and it is imported from SWITZERLAND, The most popular alternatives of MABTHERA 500mg/50ml are listed downward .

Mode Of Action

Rituximab is a chimeric monoclonal antibody to CD20 antigen which regulates cell cycle initiation. It binds to the antigen on the cell surface, activating complement-dependent B-cell cytotoxicity; and to human Fc receptors, mediating cell killing through an antibody-dependent cellular toxicity.

Indication

• Non-Hodgkin's lymphoma; follicular lymphoma

Precaution

Extensive tumor burden, pulmonary tumor infiltration or pulmonary insufficiency; history of cardiac disease; effective contraception during and up to 12 mth after treatment; pregnancy. Monitor CBC and platelet counts regularly. Premedication with analgesics, antihistamines and corticosteroids may be recommended. Monitor for signs of active infection or hepatitis in hepatitis B carriers. Discontinue treatment if viral hepatitis develops. Lactation: not known if excreted in breast milk, do not nurse

Side Effects

• >10% NHL Angioedema (11%)
• hypotension (10%)
• Asthenia (26%)
• chills (33%)
• dizziness (10%)
• fever (53%)
• headache (19%) Pruritus (14%)
• rash (15%)
• Abdominal pain (14%)
• diarrhea (10%)
• nausea (23%)
• vomiting (10%) Leukopenia (14%)
• lymphopenia (48%)
• neutropenia (14%)
• thrombocytopenia (12%)
• Back pain (10%)
• myalgia (10%) Cough (13%)
• rhinitis (12%)
• Infection (31%)
• night sweats (15%) 1-10% NHL Edema
• Flushing
• Hypertension
• Anxiety
• Anemia
• Elevated LDH
• Hyperglycemia
• Bronchospasm
• dyspnea
• sinusitis
• throat irritation
• urticaria
• RA (Rituximab+Methotrexate vs Methotrexate Alone) Hypertension
• Anxiety
• asthenia
• chills
• migraine
• paresthesia
• pyrexia
• Pruritus
• urticaria
• Dyspepsia
• nausea
• upper abd pain
• Hypercholesterolemia
• Arthralgia
• Rhinitis
• throat irritation
• URI Frequency Not Defined Tumor lysis syndrome
• Lymphoid malignancies
• Hypogammaglobulinemia Potentially Fatal: Pulmonary or cardiac toxicity during infusion; severe mucocutaneous reactions; severe cytokine release syndrome associated with tumor lysis syndrome. Toxic epidermal necrolysis.

Contra indication

Lactation. Type I hypersensitivity or anaphylactic reactions to murine proteins or component of the formulation.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks