LETARA 2.5mg Price
Active Substance: Letrozole.
Overview
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This medicine contains an important and useful components, as it consists of
Letrozoleis available in the market in concentration
Name
Letrozole
Precaution
Severe renal impairment; severe hepatic impairment; osteoporosis. Caution when driving or operating machinery. Lactation: not known if excreted in breast milk (for post-menopausal women)
Indication
Breast cancer
Contra indication
Premenopausal women and children; hypersensitivity.
Side Effect
Hot flushes, arthralgia, nausea, vomiting, fatigue, dizziness, headache, dyspepsia, constipation, diarrhoea, anorexia, alopoecia, increased sweating, rash, peripheral oedema, osteoporosis, musculoskeletal pain, vaginal irritation. Potentially Fatal: Thromboembolic events.
Pregnancy Category ID
5
Mode of Action
Letrozole competitively binds to the heme group of aromatase, a cytochrome P450 enzyme which catalyzes conversion of androgen to oestrogen, leading to inhibition of the enzyme and a significant reduction in plasma oestrogen levels.
Interaction
Plasma levels reduced by tamoxifen.
Pregnancy Category Note
Information not available
Adult Dose
Child Dose
Renal Dose
Administration
