ICLUSIG 45mg Price

Overview

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This medicine contains an important and useful components, as it consists of
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Name

Fusidic Acid 2% + Hydrocortisone Acetate 1% Topical

Precaution

Fusidic Acid 2% + Hydrocortisone Acetate 1% topical cream should be used cautiously in patients with a history of hypersensitivity to either fusidic acid or hydrocortisone or any of the excipients in the formulation. It should not be applied to large areas of broken or compromised skin or for prolonged periods, as the risk of systemic absorption increases, particularly with the corticosteroid component. Prolonged use of hydrocortisone on the skin can lead to thinning of the skin (atrophy), delayed wound healing, or secondary skin infections. Patients with a history of fungal or viral skin infections (such as herpes simplex or chickenpox) should avoid using this combination, as corticosteroids can exacerbate these conditions. Additionally, it should be used with caution in patients with conditions like tuberculosis, as corticosteroids may activate latent infections. Pregnant and breastfeeding women should consult their healthcare provider before using this combination, as corticosteroids can cross the placenta and be excreted in breast milk. The cream should not be applied near the eyes or mucous membranes, as the corticosteroid can increase the risk of glaucoma or other ocular complications. Regular monitoring for signs of skin irritation or infection is recommended during use.

Indication

Fusidic Acid 2% + Hydrocortisone Acetate 1% topical cream is indicated for the treatment of inflammatory skin conditions that are complicated by bacterial infections. The fusidic acid component provides antibacterial action against Gram-positive bacteria, particularly *Staphylococcus aureus*, including methicillin-resistant strains (MRSA), making it useful for treating infected eczema, impetigo, and other localized skin infections. The hydrocortisone acetate, a mild corticosteroid, helps reduce inflammation, itching, and redness associated with these conditions. This combination is typically used for short-term management of inflammatory skin disorders where both infection and inflammation are present. Off-label, it may be used for conditions like dermatitis, psoriasis with secondary infection, and insect bites complicated by bacterial infection. However, the corticosteroid component limits its long-term use due to the potential for side effects like skin thinning and increased susceptibility to secondary infections. Evidence supports its effectiveness for treating mild to moderate bacterial skin infections with an inflammatory component, especially in patients who have not responded well to other topical treatments.

Contra indication

Fusidic Acid 2% + Hydrocortisone Acetate 1% is contraindicated in patients with known hypersensitivity to fusidic acid, hydrocortisone, or any other ingredients in the formulation. It should not be applied to areas with fungal or viral skin infections (e.g., herpes simplex, chickenpox), as hydrocortisone can worsen these conditions. This combination is also contraindicated in patients with tuberculosis of the skin, as corticosteroids can promote the activation of latent tuberculosis. Patients with severe skin atrophy or other dermatological conditions that may be exacerbated by steroids should not use this combination. Due to the corticosteroid content, the cream should be avoided near the eyes, as it can lead to increased intraocular pressure or glaucoma if applied over long periods. Additionally, it should not be used in deep or puncture wounds, or in the case of burns or large skin ulcers, where the absorption of both fusidic acid and hydrocortisone may be higher, increasing the risk of systemic side effects. There are no age restrictions, but special caution should be exercised in children due to their thinner skin, which may absorb more of the medication.

Side Effect

The most common side effects of Fusidic Acid 2% + Hydrocortisone Acetate 1% topical cream are mild and typically localized to the area of application. These include burning, stinging, redness, or itching, which are usually transient and subside after discontinuation of the treatment. Prolonged use of the corticosteroid component can cause skin thinning (atrophy), striae (stretch marks), and delayed wound healing, especially if used over large areas or for extended periods. Secondary fungal or bacterial infections can also occur due to the corticosteroid’s immunosuppressive effects, which may allow opportunistic pathogens to proliferate. In rare cases, allergic reactions such as contact dermatitis, hives, or swelling may occur. Long-term use of corticosteroids on the skin can also lead to the development of telangiectasia (spider veins) or acneiform eruptions. Serious side effects are rare but can include signs of systemic absorption of the corticosteroid, such as weight gain, elevated blood sugar levels, or adrenal suppression. If any severe reactions occur, such as difficulty breathing, swelling of the face or throat, or signs of infection, medical attention should be sought immediately.

Pregnancy Category ID

0

Mode of Action

Fusidic Acid 2% + Hydrocortisone Acetate 1% cream combines two distinct mechanisms to address both infection and inflammation. Fusidic acid works by inhibiting bacterial protein synthesis. It binds to the elongation factor G (EF-G) in bacteria, preventing the ribosome from translocating along the mRNA, thus halting bacterial protein synthesis and inhibiting bacterial growth. Fusidic acid is particularly effective against *Staphylococcus aureus* and other Gram-positive organisms, including resistant strains like MRSA. Hydrocortisone, a mild corticosteroid, exerts its anti-inflammatory effects by binding to glucocorticoid receptors in cells. This binding activates a series of cellular responses that reduce the production of pro-inflammatory cytokines and inhibit the activity of immune cells involved in the inflammatory process. This action helps to reduce symptoms such as redness, swelling, and itching associated with inflammatory skin conditions. The combination of these two drugs makes this formulation particularly useful for treating bacterial skin infections that are inflamed or pruritic, as it addresses both the infection and the underlying inflammation simultaneously.

Interaction

Fusidic Acid 2% + Hydrocortisone Acetate 1% topical cream has minimal systemic absorption when applied as directed, so drug-drug interactions are rare. However, corticosteroids like hydrocortisone can enhance the absorption of other topically applied medications, which may increase the risk of systemic effects, especially when used over large areas or for extended periods. The combination should not be used with other topical treatments containing steroids or potent antibiotics, as this may increase the risk of side effects, including skin thinning, delayed wound healing, or secondary infections. Patients using other corticosteroid medications systemically should be cautious, as there is a potential for additive effects. There are no significant interactions with food, alcohol, or lifestyle habits when using this topical medication, but patients should avoid applying the cream to broken skin where absorption may be increased. As with any topical medication, it is recommended to avoid contact with the eyes and mucous membranes. Patients should inform their doctor about all medications they are taking, including other topical agents, to avoid potential adverse interactions.

Pregnancy Category Note

Information not available

Adult Dose

The typical adult dosage for Fusidic Acid 2% + Hydrocortisone Acetate 1% topical cream is to apply a thin layer of the cream to the affected area 2–3 times daily, depending on the severity of the condition. It is important to use the medication sparingly to minimize the risk of side effects, particularly with prolonged use of hydrocortisone. The treatment duration should generally not exceed 7–14 days unless directed by a healthcare provider, as extended use of corticosteroids can lead to adverse effects such as skin thinning. The patient should be instructed to avoid applying the cream to mucous membranes, large wounds, or areas of broken skin where absorption might be increased. If no improvement is seen after a few days of use, or if the infection or inflammation worsens, patients should consult their healthcare provider for further evaluation and potential adjustment of treatment.

Child Dose

The use of Fusidic Acid 2% + Hydrocortisone Acetate 1% topical cream in children should be carefully monitored. In general, the cream can be applied to the affected area two to three times daily, with a thin layer applied sparingly to avoid excessive systemic absorption, especially in younger children whose skin is more permeable. The duration of treatment in children should be limited to 7–14 days to reduce the risk of side effects, particularly skin thinning, and the use of the cream should be avoided on large areas of the body or broken skin. As children have a greater skin surface-area-to-body weight ratio than adults, their absorption of both fusidic acid and hydrocortisone may be higher, so caution is recommended. Monitoring for signs of adverse reactions, such as skin irritation, fungal infection, or delayed wound healing, is crucial during treatment. Always consult a pediatric healthcare provider before using this combination in children, especially infants.

Renal Dose

Fusidic Acid 2% + Hydrocortisone Acetate 1% topical cream does not require specific dose adjustments for patients with renal impairment, as the systemic absorption is minimal when used topically. However, if applied to large areas of broken skin, or in cases of systemic absorption, careful monitoring of renal function may be warranted. In patients with severe renal impairment, any potential systemic effects from corticosteroid absorption should be considered, as these may increase the risk of complications such as fluid retention or elevated blood sugar. If systemic therapy is required for more extensive infections, renal function should be taken into account when dosing systemic antibiotics or corticosteroids.

Administration

Information not available