Active Substance: Hyaluronidase.
Overview
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This medicine contains an important and useful components, as it consists of
Hyaluronidaseis available in the market in concentration
Hyaluronidase
Impaired renal function. Infants, elderly. Patients with infections. Pregnancy, lactation. Lactation: It is not known whether hyaluronidase is excreted in human milk; caution should be exercised
Hypodermoclysis, Facilitate SC/IM inj, Aid in dispersal of extravasated fluids or blood, Aid in diffusion of local anesthesia in ophthalmology
Hypersensitivity, malignancy. Direct application to the cornea, reduction of swelling of bites or stings. Inj into or around infected area. IV admin; unexplained premature labour.
<1% Angioedema, urticaria, allergic reactions (<0.1%) Frequency Not Defined Edema,Local injection site reactions Potentially Fatal: Hypersensitivity and anaphylaxis.
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Hyaluronidase is an enzyme which reduces the viscosity of ground substance, thus making the tissues more permeable to injected fluids. It facilitates distribution and absorption of locally injected substances. It also promotes resorption of excess fluids and extravasated blood in the tissues.
Action potentiated by urokinase especially in the treatment of MI. May increase absorption and toxicity of local anaesthetics. Heparin, salicylates and NSAIDs may inhibit the spreading action and efficacy of hyaluronidase.
Information not available