Glucose 10% w/v Intravenous Infusion B.P Price

Overview

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Name

Terbinafine Topical

Precaution

Before using **Terbinafine Topical**, it is important to consult a healthcare provider due to the following precautions: - **Skin Irritation**: **Terbinafine Topical** can cause mild skin irritation, such as redness, itching, or stinging, especially when applied to broken or irritated skin. Patients should discontinue use if irritation becomes severe or persists. - **Application to Open Wounds**: The topical formulation should not be applied to open wounds, or in areas with extensive skin damage, as it may be absorbed into the bloodstream and increase the risk of systemic side effects. - **Avoid Contact with Eyes**: The medication should be applied carefully to avoid contact with the eyes. If contact occurs, the area should be rinsed thoroughly with water. If irritation persists, medical attention should be sought. - **Liver Function**: Though **Terbinafine Topical** is used locally, patients with a history of **liver disease** should be monitored, especially if using other systemic **Terbinafine** treatments. - **Pregnancy and Breastfeeding**: **Terbinafine Topical** is generally considered safe during pregnancy and breastfeeding, but as with all medications, it should be used only when necessary. Consult a healthcare provider before use during pregnancy or breastfeeding.

Indication

**Terbinafine Topical** is used to treat various superficial fungal infections, including: - **Tinea Pedis (Athlete’s Foot)**: Fungal infections of the feet caused by dermatophytes. It is one of the most common uses for **Terbinafine Topical**. - **Tinea Cruris (Jock Itch)**: Fungal infections of the groin area caused by dermatophytes. - **Tinea Corporis (Ringworm)**: A fungal infection of the skin characterized by ring-shaped lesions. - **Tinea Versicolor**: A fungal infection that causes discolored patches on the skin, usually caused by Malassezia species. - **Candida Infections**: **Terbinafine Topical** can be used to treat **cutaneous Candida** infections when other topical antifungal treatments are not effective.

Contra indication

**Terbinafine Topical** should not be used in the following cases: - **Hypersensitivity**: Contraindicated in patients with known **allergy** to **Terbinafine** or any component of the formulation. This may cause severe allergic reactions such as **rashes**, **swelling**, or **difficulty breathing**. - **Open Wounds**: **Terbinafine Topical** should not be applied to broken or irritated skin where there are open wounds, as this can lead to systemic absorption and increase the risk of side effects. - **Eye Exposure**: Avoid using **Terbinafine Topical** near the eyes. If accidental exposure occurs, the eyes should be thoroughly rinsed with water. **Terbinafine** should be discontinued if irritation persists.

Side Effect

**Terbinafine Topical** is generally well tolerated, but some side effects may occur, including: - **Common Side Effects**: - **Skin Irritation**: Redness, itching, or burning at the application site. - **Dry Skin**: Some users may experience dryness at the application site. - **Rash**: Mild rash may occur, particularly in individuals with sensitive skin. - **Serious Side Effects**: - **Severe Allergic Reactions**: Although rare, allergic reactions such as **hives**, **swelling**, and **difficulty breathing** can occur. If these symptoms occur, use should be discontinued immediately, and medical attention should be sought. - **Severe Skin Reactions**: Rarely, **Stevens-Johnson Syndrome (SJS)** or **Toxic Epidermal Necrolysis (TEN)**, both of which are serious skin conditions that cause blistering, can occur with any topical medication, including **Terbinafine**. - **Systemic Absorption**: In rare cases, especially if applied to large areas of broken skin, there could be **systemic absorption** leading to symptoms such as liver dysfunction (e.g., jaundice, dark urine, and loss of appetite). These cases are uncommon but should be monitored.

Pregnancy Category ID

2

Mode of Action

**Terbinafine** works by inhibiting **squalene epoxidase**, an enzyme involved in the synthesis of **ergosterol**, a key component of the fungal cell membrane. The inhibition of this enzyme leads to a deficiency in ergosterol and an accumulation of **squalene**, which is toxic to the fungal cell. This disrupts the integrity of the fungal membrane, causing fungal cell death. **Terbinafine** has a broad spectrum of activity against various dermatophytes, yeasts, and fungi, making it effective for treating superficial fungal infections on the skin.

Interaction

**Terbinafine Topical** is unlikely to interact with other medications significantly when used as directed, due to its local application. However, the following considerations should be kept in mind: - **Topical Corticosteroids**: When combined with **topical corticosteroids**, **Terbinafine** may reduce the effectiveness of the steroid, especially in treating fungal infections. - **Other Topical Antifungals**: While it is generally safe to use **Terbinafine** with other topical antifungals, caution should be exercised to prevent overuse of antifungal medications, which may lead to skin irritation or fungal resistance.

Pregnancy Category Note

Information not available

Adult Dose

For **Terbinafine Topical**, the typical dosing instructions for adults are: - **Tinea Pedis (Athlete’s Foot)**: Apply **Terbinafine** topical cream, gel, or spray once or twice daily to the affected area. Treatment duration is typically **1 to 2 weeks**. - **Tinea Cruris (Jock Itch)**: Apply **Terbinafine** to the affected area once or twice daily for **1 to 2 weeks**. - **Tinea Corporis (Ringworm)**: Apply **Terbinafine** once or twice daily for **1 to 4 weeks**. - **Tinea Versicolor**: Apply **Terbinafine** daily to the affected areas for **2 weeks**.

Child Dose

**Terbinafine Topical** can be used in children over **12 years** of age, following adult dosing instructions. The safety and efficacy of **Terbinafine Topical** in children under 12 years old have not been well established. For pediatric patients, the application should be done as directed by a healthcare provider. --- **Terbinafine Topical** is a highly effective treatment for superficial fungal infections of the skin, such as athlete's foot, jock itch, and ringworm. It works by inhibiting fungal cell membrane synthesis, leading to fungal cell death. While it is generally safe for most patients, it is essential to use the medication as directed to avoid skin irritation or other side effects. Always consult a healthcare provider before starting **Terbinafine Topical**, especially for pediatric patients, individuals with underlying skin conditions, or those using other medications.

Renal Dose

**Terbinafine Topical** is not systemically absorbed in significant amounts when used topically, and therefore **renal dosing adjustments** are typically not necessary. However, patients with **severe renal impairment** should still use caution, and it is recommended to follow the prescribed dosage carefully to avoid potential overuse or adverse reactions.

Administration

Information not available