GLADOS-MET 15/850 mg Price

Overview

Welcome to Dwaey, specifically on GLADOS-MET 15/850 mg Tablet/Film coated page.
This medicine contains an important and useful components, as it consists of Pioglitazone Ð Metformin hydrochloride -.
GLADOS-MET 15/850 mg is available in the market in concentration 15 mg/tablet, 850 mg/tablet and in the form of Tablet/Film coated.

TABUK PHARMACEUTICAL MANUFACTURING CO is the producer of GLADOS-MET 15/850 mg and it is imported from SAUDI ARABIA, The most popular alternatives of GLADOS-MET 15/850 mg are listed downward .

Mode Of Action

Pioglitazone is as a potent and highly selective agonist for the peroxisome proliferator activated receptor-gamma. Activation of these receptors promotes the production of gene products involved in lipid and glucose metabolism. It also improves insulin response to target cells witho increasing the pancreatic secretion of insulin. Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).

Indication

• Type 2 DM

Precaution

Patient w/ oedema, anaemia. Premenopausal, anovulatory women. Pregnancy. Patient Counselling This drug may cause visual disturbance, if affected, do not drive or operate machinery. Monitoring Parameters Monitor HbA1c, serum glucose; signs and symptoms of oedema or heart failure, bladder cancer; liver enzymes, haematologic parameters, renal function; vit B12 and folate if anaemia is present. Routine ophth examination. Lactation: not known if crosses into breast milk, avoid using in nursing women

Side Effects

• >10% Lower limb edema (2.9-11.3%)
• Upper respiratory infection (12-16) 1-10% Weight gain (2.9-6.7%)
• Diarrhea (4.8-5.8%)
• Nausea (3.6-5.8%)
• Urinary tract infection (5.3-5.8%)
• Dizziness (4.8-5.4%)
• Headache (4.6-5.3%)
• Sinusitis (4.4-5%)
• Edema (3%)

Contra indication

Renal disease or renal dysfunction (e.g. as suggested by serum creatinine levels >1.5 mg/dl in male, >1.4 mg/dl in females or abnormal creatinine clearance), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction and septicemia.Current or history of cardiac failure, active or history of bladder cancer, Known hypersensitivity to Pioglitazone, Metformin or any other component of this combination. Acute or chronic metabolic acidosis including diabetic ketoacidosis with or without coma.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks