GANCIL 450 Price
Active Substance: Valganciclovir (as HCl).
Overview
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This medicine contains an important and useful components, as it consists of
Valganciclovir (as HCl)is available in the market in concentration
Name
Valganciclovir
Precaution
Patient w/ pre-existing haematological cytopenia, history of drug-related haematological cytopenia. Renal impairment. Pregnancy. Lactation: not known if distributed in breast milk; do not nurse
Indication
Cytomegalovirus infections
Contra indication
Hypersensitivity. Haemodialysis patients (CrCl <10 mL/min). Lactation. Should not be administered if the absolute neutrophil count is <500 cells/?L, platelet count is <25,000/?L, or Hb is <8 g/dL.
Side Effect
>10% Abdominal pain (15%),Anemia (8-26%),Diarrhea (16-41%),Fever (31%),Granulocytopenia (11-27%),Headache (9-22%),Insomnia (16%),Nausea (8-30%),Retinal detachment (15%),Vomiting (21%) 1-10% Peripheral neuropathy (9%),Paresthesia (8%),Seizures (<5%),Psychosis, hallucinations (<5%),Confusion (<5%),Agitation (<5%),Thrombocytopenia (8%),Pancytopenia (<5%),Bone marrow depression (<5%),Aplastic anemia (<5%),Bleeding, potentially life-threatening due to thrombocytopenia (<5%),Decr renal function (<5%),,Local & systemic infections, incl sepsis (<5%),Allergic reaction (<5%)
Pregnancy Category ID
3
Mode of Action
Valganciclovir is an L-valyl ester (prodrug) of ganciclovir that exists as a mixture of 2 diastereomers. After oral admin, both diastereomers are rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is a synthetic analogue of 2'-deoxyguanosine, which inhibits replication of human cytomegalovirus (CMV) in cell culture and in vivo.
Interaction
Convulsions may occur if taken concomitantly w/ imipenem-cilastatin. Increased exposure w/ probenecid. Increased risk of neutropenia and anaemia w/ zidovudine. May increase plasma concentrations of didanosine. Increased risk of neutropenia and leucopenia w/ mycophenolate mofetil. Increased risk of peripheral neuropathy w/ zalcitabine. Enhanced toxicity w/ other drugs that inhibit replication of rapidly dividing cells (e.g. dapsone, vincristine, vinblastine, amphotericin B, trimethoprim/sulfa combinations, nucleoside analogues, hydroxyurea), cidofovir, foscamet.
Pregnancy Category Note
Information not available
Adult Dose
Child Dose
Renal Dose
Administration
