FARMORUBICIN RAPID DISSOLUTION 10mg/5ml Price in UAE

Overview

Welcome to Dwaey, specifically on FARMORUBICIN RAPID DISSOLUTION 10mg/5ml page.
This medicine contains an important and useful components, as it consists of
Epirubicin HClis available in the market in concentration

Name

Epirubicin Hydrochloride

Precaution

Previous extensive radiotherapy, bone infiltration by tumour, severe renal and hepatic dysfunction. May cause tumor lysis syndrome or radiation recall. Elderly women >70 yr. CV disease, hypertensive cardiomyopathy; monitor hematological and cardiac function regularly. Extravasation during IV admin may result in severe local tissue necrosis. Do not give via IM/SC routes as extravasation can lead to severe local necrosis. Lactation: not known if excreted in breast milk; do not nurse

Indication

Acute leukaemias; Lymphoma; Multiple myeloma, Breast cancer, Bladder carcinoma

Contra indication

Cardiac impairment, severe or recent MI; previous full cumulative doses of anthracyclines. Hypersensitivity; severe hepatic dysfunction. Not for intravesical use where invasive tumours have penetrated the bladder wall; urinary infections, bladder inflammation or catheterisation problems. Pregnancy, lactation.

Side Effect

>10% Alopecia (96%),Nausea and vomiting (92%),Leukopenia or neutropenia (80%),Amenorrhea (72%),Anemia (72%),Mucositis (59%),Thrombocytopenia (49%),Lethargy (46%),Hot flashes (39%),Diarrhea (25%),Conjunctivitis (15%) 1-10% Rash (9%),Fever (5%),Skin changes (5%),Anorexia (3%) <1% Acute lymphoid leukemia,Acute myelogenous leukemia,Atrioventricular block,Esophagitis,Hyperpigmentation,Myelodysplastic syndrome Frequency Not Defined Myocardial toxicity (including CHF),Severe myelosuppression,Risk of secondary AML

Pregnancy Category ID

4

Mode of Action

Epirubicin, an anthracycline with cytotoxic properties. It inhibits DNA and RNA synthesis by steric obstruction after intercalating between DNA base pairs that triggers DNA cleavage by by topoisomerase II. It also inhibits DNA helicase and generates cytotoxic free radicals.