Active Substance: Flutamide.
Overview
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This medicine contains an important and useful components, as it consists of
Flutamideis available in the market in concentration
Flutamide
Perform liver function tests before starting treatment and at regular intervals. Treatment is not recommended in patients whose ALT values exceed twice the upper limit of normal. Regular assessment of prostate specific antigen level may help to monitor disease progression. Advise patient against discontinuing drug on their own. Exercise caution in patients with cardiac disease. Lactation: Excretion in milk unknown; not recommended
Prostate cancer
Hypersensitivity, severe hepatic impairment, pregnancy and lactation.
>10% Hot flashes (61%),Decreased libido (36%),Impotence (31%),Diarrhea (12%),Nausea/vomiting (11%) 1-10% Gynecomastia (9%),Anorexia (4%),Edema (4%),Leukopenia (3%),Rash (3%) Frequency Not Defined Hemolytic anemia, methemoglobinemia Increased AST, ALT, bilirubin, BUN
4
Flutamide is a nonsteroidal 'pure' antiandrogen which acts directly on the target tissues either by blocking androgen uptake or by inhibiting cytoplasmic and nuclear binding of androgen.
Increased prothrombin time in patients on long-term warfarin treatment.
Information not available