Active Substance: Adapalene/Benzoyl Peroxide.
Overview
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This medicine contains an important and useful components, as it consists of
Adapalene/Benzoyl Peroxideis available in the market in concentration
Adapalene 0.1% + Benzoyl Peroxide 2.5%
Exposure to sunlight, including sunlamps, should be minimized during the use of adapalene and benzoyle peroxide gel. Patients with high levels of sun exposure and those with inherent sensitivity to sun should exercise particular caution. Use of sunscreen products and protective apparel, (e.g., hat) are recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, may be irritating to patients under treatment with adapalene and benzoyle peroxide gel. Safety and effectiveness of Adapalene and Benzoyl peroxide gel in pediatric patients under the age of 9 years have not been established.
Acne
Hypersensitive to any of the components.
>10% Stinging/ burning (3-41%),Dryness (1-41%),Scaling (1-35%),Erythema (1-27%) 1-10% Contact dermatitis (3%),Application site burning (2%),Application site irritation (1%),Skin irritation (1%)
3
Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Benzoyl peroxide has mild keratolytic effect and antimicrobial activity which is attributed to its oxidative property. It is active against S.epidermidis and P.acne.
Adapalene: Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents. Benzoyl Peroxide: PABA sunscreens may transiently discolour fabric.
Information not available