DUROGESIC 100mcg/hr Price

Overview

Welcome to Dwaey, specifically on DUROGESIC 100mcg/hr page.
This medicine contains an important and useful components, as it consists of
Fentanylis available in the market in concentration

Name

Fentanyl

Precaution

Myasthaenia gravis. Head injury; increased intracranial pressure; intracranial lesions; renal or hepatic impairment; neonates; opioid-nontolerant patients. Increased risk of respiratory depression in elderly, debilitated patients, patient with hypoxia or hypercapnia. Hypothyroidism, prostatic hyperplasia, inflammatory bowel disorders, bradycardia or bradyarrhythmias. Rapid IV infusion may cause skeletal muscle and chest wall rigidity, impaired ventilation or respiratory distress/arrest. Prolonged use may cause tolerance, psychological and physical dependence. Abrupt withdrawal after prolonged admin may lead to withdrawal symptoms. Lactation. Pregnancy (avoid high doses or prolonged usage). Lactation: Drug distributed in breast milk; breastfeeding not recommended

Indication

Pain, Cancer pain, Anesthesia, Analgesia, Breakthrough pain

Contra indication

Hypersensitivity.

Side Effect

Reduce pulmonary compliance and/or apnoea, bronchoconstriction, laryngospasm; nausea, vomiting; bradycardia, oedema, CNS depression, confusion, dizziness, drowsiness, headache, sedation, hypotension, peripheral vasodilation, increased intracranial pressure, itching, rash, erythema, papules, pruritus, exfoliative dermatitis, pustules, macular rash; gum bleeding and irritation, taste perversion, dental caries, tooth loss, gum line erosion; throat irritation, nasal ulcers, epistaxis, rhinorrhoea; coughing; urinary retention. High IV dose may cause chest wall rigidity. Transdermal: Rash, erythema and itching. Potentially Fatal: Respiratory depression, trunk rigidity, laryngospasm, bronchoconstriction.

Pregnancy Category ID

3

Mode of Action

Fentanyl is a potent opioid analgesic that increases pain threshold, alters pain reception and inhibits ascending pain pathways by binding to stereospecific receptors w/in the CNS.

Interaction

Concomitant use w/ CYP3A4 inhibitors (e.g. erythromycin, clarithromycin, troleandomycin, azole antifungals, ritonavir, amiodarone, nefazodone, aprepitant, diltiazem and verapamil) increases serum levels of fentanyl and may potentiate fatal resp depression. Increased risk of life-threatening serotonin syndrome w/ SSRIs, SNRIs and MAOIs. May reduce serum levels w/ rifamycin derivatives. Enhanced depressant effect w/ general anaesth, tranquilisers, barbiturates and narcotics. May increase excretion w/ ammonium Cl. May increase hypotensive effect w/ phenothiazines. May reduce efficacy of pegvisomant.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration