DOPANORE 250mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Methyldopa (anhydrous)is available in the market in concentration

Name

Methyldopa

Precaution

Patient w/ history of haemolytic anaemia, liver disease or depression; parkinsonism, hepatic porphyria. Not intended for the treatment of phaeochromocytoma. Renal or hepatic impairment. Childn, elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor BP, blood counts, liver enzymes; direct Coombs' test. Lactation: distributed in breast milk but not in clinically significant amounts; compatible w/ breastfeeding

Indication

Hypertension

Contra indication

Active liver disease (e.g. acute hepatitis, active cirrhosis) or depression. Concomitant use w/ MAOIs.

Side Effect

Drowsiness, orthostatic hypotension, nausea, headache, weakness, fatigue, decreased libido, impotence, impaired concentration and memory, mild psychoses, depression, disturbed sleep, nightmares, paraesthesias, Bell's palsy, parkinsonism, involuntary choreoathetotic movements, oedema, fluid retention, exacerbation of angina pectoris, bradycardia, syncope, prolonged carotid sinus hypersensitivity, paradoxical HTN, GI disturbances (e.g. nausea, vomiting, diarrhoea, constipation), black/sore tongue, inflamed salivary glands, dry mouth, fever, eosinophilia, liver function disturbances, hepatitis, lupus-like syndrome, rashes, lichenoid and granulomatous eruptions, toxic epidermal necrolysis, flu-like syndrome, nocturia, uraemia, nasal congestion, retroperitoneal fibrosis, hyperprolactinaemia, breast enlargement (including gynaecomastia), galactorrhoea, amenorrhoea. Rarely, pancreatitis and colitis, immune thrombocytopenia, reversible leucopenia (primarily granulocytopenia). Potentially Fatal: Hepatic necrosis, haemolytic anaemia, hypersensitivity myocarditis.

Pregnancy Category ID

2

Mode of Action

Methyldopa stimulates alpha 2-adrenoceptors which results in reduced sympathetic tone and fall in BP.

Interaction

Reduced hypotensive effects with phenothiazines, TCAs and possibly, amphetamines. Additive hypotensive effects with levodopa; psychosis may also occur. Reduced absorption and effects with oral iron preparations. Reduced doses of general anaesthetics may be required. Effect of ephedrine may be reduced. Potentially Fatal: Increased risk of severe hypertension with MAOIs. Increased lithium toxicity

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration