COUFATEX 5mg Price

Overview

Welcome to Dwaey, specifically on COUFATEX 5mg Tablets page.
This medicine contains an important and useful components, as it consists of Warfarin sodium.
COUFATEX 5mg is available in the market in concentration 5mg/Tablet and in the form of Tablets.

APOTEX INC. is the producer of COUFATEX 5mg and it is imported from CANADA, The most popular alternatives of COUFATEX 5mg are listed downward .

Mode Of Action

Warfarin inhibits synthesis of vit K-dependent coagulation factors VII, IX, X and II and anticoagulant protein C and its cofactor protein S. No effects on established thrombus but further extension of the clot can be prevented. Secondary embolic phenomena are avoided.

Indication

• Venous thromboembolism
• Stroke prevention
• Deep vein thrombosis

Precaution

Any condition where added risk of haemorrhage, necrosis and/or gangrene is present. Patient w/ heparin-induced thrombocytopenia, infectious diseases or disturbances of intestinal flora (e.g. sprue), indwelling catheters, moderate to severe HTN, vit C or K deficiency, known or suspected deficiency in protein C-mediated anticoagulant response, polycythemia vera, vasculitis, DM. Moderate to severe hepatic or renal impairment. Elderly. Lactation. Patient Counselling Eat a balanced diet w/ a constant amount of vit K. Avoid ingestion of large quantities of certain foods that contain a large amount of vit K (e.g. leafy green vegetables, certain vegetable oils), drastic changes in diet and activities or sports that could cause traumatic injury. Monitoring Parameters Monitor prothrombin time, haematocrit, INR (frequency varies depending on INR stability); may consider genotyping of CYP2C9 and VKORC1 prior to initiation of therapy, if available. Lactation: Not excreted in breast milk as reported in limited published study (AAP Committee states compatible with nursing); because of potential for serious adverse reactions, including bleeding in breastfed infant, consider developmental and health benefits of breastfeeding along with mother’s clinical need for therapy; monitor breastfeeding infants for bruising or bleeding

Side Effects

• Hemorrhage is the principal adverse effect of oral anticoagulants. Jaundice
• hepatic dysfunction
• vasculitis
• pancreatitis
• nausea
• vomiting
• diarrhoea
• taste perversion
• abdominal pain
• flatulence
• bloating
• rash
• purpura
• erythematous swollen skin patches leading to ecchymosis
• pruritus
• alopecia
• purple discolouration of toes due to cholesterol embolisation
• tracheal or tracheobronchial calcification
• fever
• chills. Unexplained drop in haematocrit
• decreased Hb. Rarely
• hypersensitivity reactions. Potentially Fatal: Haemorrhage from almost any organ of the body w/ the consequent effects of haematomas as well as anaemia
• tissue necrosis and/or gangrene of skin or other tissues w/ SC infarction.

Contra indication

Patient w/ haemorrhagic tendencies or blood dyscrasias, recent or contemplated surgery of the CNS or eye, those undergoing traumatic surgery resulting in large open surfaces, overt bleeding or active ulceration involving the GI, genitourinary or resp tract, cerebrovascular haemorrhage, cerebral aneurysms, dissecting aorta, pericarditis and pericardial effusions, bacterial endocarditis, threatened abortion, eclampsia, pre-eclampsia, malignant HTN. Unsupervised patients w/ conditions associated w/ potential high level of non-compliance, spinal puncture and other diagnostic or therapeutic procedures w/ potential for uncontrolled bleeding, major regional or lumbar block anaesth. Concomitant use w/ fibrinolytic drugs (e.g. streptokinase, alteplase). Pregnancy.

Pregnancy and lactation

Pregnancy category: X

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.