COSOPT 2% / 0.5% Price

Overview

Welcome to Dwaey, specifically on COSOPT 2% / 0.5% Eye Drops (Solution) page.
This medicine contains an important and useful components, as it consists of Dorzolamide (as HCl), Timolol (as maleate).
COSOPT 2% / 0.5% is available in the market in concentration 20mg, 5mg/ml and in the form of Eye Drops (Solution).

MERCK SHARP & DOHME B.V. is the producer of COSOPT 2% / 0.5% and it is imported from NETHERLANDS, The most popular alternatives of COSOPT 2% / 0.5% are listed downward .

Mode Of Action

Timolol maleate, a nonselective beta-adrenergic blocker, reduces aqueous humor formation. Dorzolamide, a carbonic anhydrase inhibitor, has actions similar to acetazolamide. By inhibiting carbonic anhydrase in the ciliary processes of the eye, dorzolamide decreases aqueous humor secretion. Used together, there is additional intraocular pressure reduction compared to using either component alone, but the reduction is not as much as concomitant admin of dorzolamide tid and timolol bid.

Indication

• Open-angle glaucoma
• Ocular hypertension

Precaution

Hepatic impairment, mild to moderate renal impairment, children <2 yr. Avoid use in pregnancy and lactation. Prinzmetal's angina, cardiac disease, hypotension, myasthenia gravis, history of renal calculi, history of intra-ocular surgery, pre-existing chronic corneal defects. May worsen severe peripheral and central circulatory disorders. May mask symptoms of hypoglycaemia and hyperthyroidism. Withdraw gradually, especially in patients with coronary heart disease. Discontinue treatment at the first signs or symptoms of cardiac failure. Contact lenses to be removed before eyedrop application and wait at least 15 minutes before reinsertion. Apply other eyedrops 10 minutes apart. May affect ability to drive or operate machinery as it may cause blurred vision. Lactation: Excreted in breast milk; not recommended

Side Effects

• >10% Dorzolamide Ocular burning
• stinging
• discomfort (33%)
• Bitter taste (25%)
• Superficial punctate keratitis (10-15%)
• Ocular allergic reactions (10%) Frequency Not Defined Dorzolamide
• Blurred vision
• Ocular dryness
• Photophobia
• Ocular redness
• Tearing
• Stevens-Johnson syndrome
• Toxic epidermal necrolysis Timolol Arrythmia
• Bradycardia
• Syncope
• Fatigue
• Headache
• Dyspnea
• Bronchospasm
• Chest pain
• Edema
• Paresthesia
• Nausea
• Rales
• Depression
• Decreased exercise tolerance
• Raynaud's phenomenon Potentially Fatal: Cardiac failure
• bronchospasm.

Contra indication

Hypersensitivity to any of the components or sulphonamide. History or current bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock, CrClr <30 ml/min and hyperchloraemic acidosis.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks