Active Substance: Irbesartan.
Overview
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This medicine contains an important and useful components, as it consists of
Irbesartanis available in the market in concentration
Irbesartan
Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy. Lactation: Potential harm to nursing infant; discontinue drug, or do not nurse
Diabetic nephropathy, Hypertension
Hypersensitivity; pregnancy and lactation.
>10% Hyperkalemia (19%) 1-10% Dizziness (10%),Upper respiratory tract infection (URTI) (9%),Orthostatic hypotension (5%),Fatigue (4%),Diarrhea (3%),Dyspepsia (2%)
3
Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.
May antagonise hypotensive effect and increase risk of nephrotoxicity w/ NSAIDs. May increase serum lithium levels and toxicity. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes. Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).
Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D